Understanding The Role of Ubiquitin-Conjugating Enzyme E2 in Cellular Processes

Target Name: UBE2D1

NCBI ID: G7321

UBE2D1

Understanding The Role of Ubiquitin-Conjugating Enzyme E2 in Cellular Processes

Ubiquitin-conjugating enzyme E2 (also known as UBE2D1) is a protein that plays a crucial role in the regulation of protein degradation in the cell. It is a member of the ubiquitin enzyme family 2 and is responsible for the formation of ubiquitin chains that can target and tag proteins for degradation. UBE2D1 is highly conserved across various species, and its sequence has been identified in many organisms, including humans.

UBE2D1 is a key enzyme in the degradation of many protein substrates, including membrane proteins, cytoplasmic proteins, and proteins involved in cell signaling pathways. It is highly drug target potential, as its expression and activity have been implicated in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the unique features of UBE2D1 is its ability to form ubiquitin chains with different lengths and modifications. This property makes it a versatile enzyme for the formation of specific ubiquitin chains for various protein targets. UBE2D1 can also regulate the stability of ubiquitin chains, which is important for the stability and localization of protein targets.

UBE2D1 has been shown to play a role in a variety of cellular processes, including cell signaling, DNA damage repair, and cell division. It is involved in the regulation ofMAPK/ERK signaling, cell migration, and the association of DNA damage with cancer progression . UBE2D1 has also been shown to be involved in the regulation of protein degradation in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its role in cellular processes, UBE2D1 is also a potential biomarker for a variety of diseases. Its expression has been shown to be elevated in a variety of cancer samples, including breast, ovarian, and colorectal cancer. It has also been used as a biomarker for neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

Given its potential as a drug target and biomarker, UBE2D1 is an attractive target for researchers to study and develop new treatments for a variety of diseases.

Protein Name: Ubiquitin Conjugating Enzyme E2 D1

Functions: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148)

The "UBE2D1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBE2D1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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