UCP3: A Potential Drug Target and Biomarker for Mitochondrial Uncovery

Target Name: UCP3

NCBI ID: G7352

UCP3

UCP3: A Potential Drug Target and Biomarker for Mitochondrial Uncovery

Uncoupling protein 3 (UCP3) is a protein that plays a critical role in the regulation of mitochondrial function and metabolism. It is a transmembrane protein that consists of 118 amino acids and has a calculated pI of 12.4. UCP3 is expressed in all cell types and is involved in the transfer of electrons from the mitochondrial inner to the mitochondrial outer membrane during the process of mitochondrial uncoupling.

Mitochondrial uncoupling is a critical process that allows the cell to generate ATP through a more efficient and ATP- yielding alternative to the traditional process of oxidative phosphorylation. In addition, UCP3 is known to play a key role in the regulation of mitochondrial fusion and fusion-dependent processes.

UCP3 as a Drug Target

The ability of UCP3 to regulate mitochondrial function makes it an attractive drug target for various diseases. One of the primary goals of drug development is to target UCP3 and modulate its activity to improve ATP production and reduce the risk of certain diseases.

Dietary factors, such as caloric restriction and intermittent fasting, have been shown to increase UCP3 levels and improve its function. Studies have also shown that modulating UCP3 activity can improve cellular energy metabolism and increase ATP production in various cell types.

In addition to its potential therapeutic benefits, UCP3 has also been shown to be a valuable biomarker for various diseases. The levels of UCP3 have been shown to be elevated in a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease.

UCP3 as a Biomarker

The ability of UCP3 to serve as a biomarker makes it an important tool for disease diagnosis and prognosis. The levels of UCP3 have been shown to be elevated in a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease.

For example, UCP3 levels have been shown to be elevated in various types of cancer, including breast, lung, and ovarian cancer. In addition, UCP3 levels have been found to be elevated in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

Studies have also shown that UCP3 levels are elevated in cardiovascular disease, including heart failure and myocardial infarction. This suggests that UCP3 may play a role in the pathophysiology of these diseases and could be a potential target for therapeutic intervention.

Conclusion

In conclusion, UCP3 is a protein that plays a critical role in the regulation of mitochondrial function and metabolism. Its involvement in the transfer of electrons from the mitochondrial inner to the mitochondrial outer membrane during the process of mitochondrial uncoupling makes it an attractive drug target for various diseases. In addition, UCP3 has also been shown to be a valuable biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. Further research is needed to fully understand the role of UCP3 in disease and to develop effective therapeutic interventions.

Protein Name: Uncoupling Protein 3

Functions: Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism (PubMed:21775425, PubMed:36114012). Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis (PubMed:9305858, PubMed:11171965, PubMed:12670931, PubMed:12734183). However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity (PubMed:11707458)

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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