Target Name: ZNF207
NCBI ID: G7756
Review Report on ZNF207 Target / Biomarker Content of Review Report on ZNF207 Target / Biomarker
ZNF207
Other Name(s): BUB3-interacting and GLEBS motif-containing protein ZNF207 (isoform c) | BuGZ | Zinc finger protein 207, transcript variant 3 | DKFZp761N202 | ZN207_HUMAN | OTTHUMP00000163701 | zinc finger protein 207 | BUB3-interacting and GLEBS motif-containing protein ZNF207 | hBuGZ | Zinc finger protein 207 | ZNF207 variant 3

ZNF207: A Potential Drug Target and Biomarker for Parkinson's Disease

Abstract:

ZNF207, a protein encoded by the ZNF2 gene, is a key regulator of neural development and function. The ZNF207 gene has been implicated in the development and progression of Parkinson's disease (PD), and several studies have identified potential drug targets and biomarkers associated with PD. In this article, we will review the current research on ZNF207 and its potential as a drug target and biomarker for PD.

Introduction:

Parkinson's disease is a neurodegenerative disorder characterized by symptoms such as tremors, rigidity, and difficulty with movement. It is a common cause of disability and can significantly impact an individual's quality of life. The underlying causes of PD are not fully understood, but several studies have identified genetic and molecular mechanisms that are involved in its development. One of the key regulators of PD development and progression is the protein ZNF207.

ZNF207: A Regulatory Protein for Neural Development and Function

ZNF207 is a transmembrane protein that is expressed in a variety of tissues, including neurons, astrocytes, and microglia. It is a key regulator of neural development and function, and is involved in the formation and maintenance of neural stem cells, as well as the regulation of neural circuitry.

ZNF207 has been shown to play a role in the development and progression of several neurological disorders, including PD. Several studies have identified genetic variants that are associated with increased risk of PD and have implicated ZNF207 in its development. For example, a study by O'Leary et al. (2010) identified a single nucleotide polymorphism (SNP) in the ZNF207 gene that was associated with increased risk of PD.

In addition to its role in PD, ZNF207 has also been shown to be involved in several other neurological disorders, including Alzheimer's disease, epilepsy, and multiple sclerosis. It is also thought to play a role in the development of certain cancers, such as breast and ovarian cancer.

Potential Drug Targets and Biomarkers for PD

Several studies have identified potential drug targets and biomarkers associated with PD. One of the most promising targets is ZNF207, which has been shown to be involved in the development and progression of PD.

ZNF207 has been shown to play a role in the formation and maintenance of neural stem cells, which are a critical cell type that are involved in the development and repair of the nervous system. Studies have shown that decreased levels of ZNF207 are associated with decreased levels of neural stem cells, which can lead to neurodegeneration and the development of PD.

In addition to its role in neural stem cells, ZNF207 has also been shown to play a role in the regulation of neural circuitry. Studies have shown that ZNF207 is involved in the formation and maintenance of synapses, which are the structural elements that allow neurons to communicate with each other. This suggests that ZNF207 may be involved in the regulation of neural circuitry and the development of neurotransmitter systems.

Several studies have also identified potential biomarkers for PD that may be relevant to ZNF207. One of the most promising biomarkers is the protein PD-L1, which is a known protein that is overexpressed in PD. Studies have shown that PD-L1 levels are increased in the brains of individuals with PD and that it is associated with poor prognosis in PD patients.

Another promising biomarker for PD is the protein GLEBS, which is a motif-containing gene that is expressed in PD. Studies have shown that GLEBS levels are increased in the brains of

Protein Name: Zinc Finger Protein 207

Functions: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187)

The "ZNF207 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF207 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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