ZNF224: A Potential Drug Target and Biomarker (G7767)
ZNF224: A Potential Drug Target and Biomarker
Zinc finger proteins (ZFPs) are a family of transcription factors, which play a crucial role in gene regulation and are involved in various cellular processes. ZNF224 is a specific ZFP that has gained significant attention due to its potential as a drug target or biomarker.
The ZNF224 gene is located on chromosome 6p21.2 and encodes a protein with 224 amino acid residues. ZNF224 is a key regulator of the microRNA (miRNA) pathway, which is a post-transcriptional regulatory network that plays a vital role in gene expression and cell development.
ZNF224 has been shown to have a direct impact on the miRNA pathway. It has been reported that ZNF224 can interact with several key players in the miRNA pathway, including miR-18a, miR-202, and miR-204. These interactions have been shown to alter the expression of target genes, suggesting that ZNF224 may be a valuable drug target or biomarker.
In addition to its impact on the miRNA pathway, ZNF224 has also been shown to play a role in cell signaling pathways. It has been reported to be involved in the regulation of cell adhesion, migration, and invasion, as well as in the regulation of cell survival.
The potential drug target status of ZNF224 is further supported by its function as a negative regulator of the TGF-β pathway. TGF-β is a well-known transcription factor that plays a crucial role in cell signaling and growth, and its activity is often disrupted in various diseases, including cancer.
Several studies have shown that ZNF224 can inhibit the activity of TGF-β, suggesting that it may be a potential TGF-β inhibitor. This property makes ZNF224 an attractive candidate for anti-tumor drug development.
In conclusion, ZNF224 is a ZFP that has gained significant attention due to its potential as a drug target or biomarker. Its interaction with key players in the miRNA pathway and its role in cell signaling pathways make it an attractive candidate for drug development. Additionally, Its ability to inhibit TGF-β activity further supports its potential as a TGF-β inhibitor. Further research is needed to fully understand the full potential of ZNF224 as a drug target or biomarker.
Protein Name: Zinc Finger Protein 224
Functions: May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells
The "ZNF224 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF224 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
ZNF225 | ZNF225-AS1 | ZNF226 | ZNF227 | ZNF229 | ZNF23 | ZNF230 | ZNF232 | ZNF232-AS1 | ZNF233 | ZNF234 | ZNF235 | ZNF236 | ZNF236-DT | ZNF239 | ZNF24 | ZNF248 | ZNF25 | ZNF250 | ZNF251 | ZNF252P | ZNF252P-AS1 | ZNF253 | ZNF254 | ZNF256 | ZNF257 | ZNF26 | ZNF260 | ZNF263 | ZNF264 | ZNF266 | ZNF267 | ZNF268 | ZNF271P | ZNF273 | ZNF274 | ZNF275 | ZNF276 | ZNF277 | ZNF28 | ZNF280A | ZNF280B | ZNF280C | ZNF280D | ZNF281 | ZNF282 | ZNF283 | ZNF284 | ZNF285 | ZNF285CP | ZNF286A | ZNF286B | ZNF287 | ZNF292 | ZNF295-AS1 | ZNF296 | ZNF3 | ZNF30 | ZNF300 | ZNF300P1 | ZNF302 | ZNF304 | ZNF311 | ZNF316 | ZNF317 | ZNF318 | ZNF319 | ZNF32 | ZNF32-AS1 | ZNF32-AS2 | ZNF32-AS3 | ZNF320 | ZNF321P | ZNF322 | ZNF322P1 | ZNF324 | ZNF324B | ZNF326 | ZNF329 | ZNF330 | ZNF331 | ZNF333 | ZNF334 | ZNF335 | ZNF337 | ZNF33A | ZNF33B | ZNF33BP1 | ZNF34 | ZNF341 | ZNF341-AS1 | ZNF343 | ZNF345 | ZNF346 | ZNF347 | ZNF35 | ZNF350 | ZNF350-AS1 | ZNF354A | ZNF354B
