Target Name: ZNF287
NCBI ID: G57336
Review Report on ZNF287 Target / Biomarker Content of Review Report on ZNF287 Target / Biomarker
ZNF287
Other Name(s): OTTHUMP00000064977 | Zinc finger protein with KRAB and SCAN domains 13 | ZN287_HUMAN | zinc finger protein with KRAB and SCAN domains 13 | ZKSCAN13 | zinc finger protein 287 | Zinc finger protein 287 | OTTHUMP00000064976 | MGC141923 | ZSCAN45 | MGC126536

ZNF287: A Potential Drug Target and Biomarker

Introduction

ZNF287 is a gene that encodes for a protein known as ZNF2, which plays a crucial role in the development and maintenance of neural stem cells (NSCs) in the brain. NSCs are a vital cell type that have the ability to generate new neurons and are considered the foundation of the nervous system. The identification of potential drug targets and biomarkers for NSCs has the potential to revolutionize our understanding of the mechanisms underlying neurodegenerative diseases. ZNF287 is one such gene that has received significant interest due to its potential involvement in the treatment of various neurological disorders.

The Importance of Neural Stem Cells

Neural stem cells (NSCs) are a type of cell that have the ability to generate new neurons and are considered the foundation of the nervous system. These cells are self-renewing and can differentiate into many different types of neurons, including sensory neurons , motor neurons and neuron glial cells, etc. NSCs have a crucial role in the development and maintenance of the nervous system, and are also involved in the repair and regeneration of damaged tissue.

The Identification of Potential Drug Targets

The identification of potential drug targets and biomarkers for NSCs is an exciting area of 鈥嬧?媟esearch, with the potential to revolutionize our understanding of the mechanisms underlying neurodegenerative diseases. One of the key challenges in this field is identifying genes that are involved in the maintenance and regulation of NSCs. ZNF287 is one such gene that has received significant interest due to its potential involvement in the treatment of various neurological disorders.

The Potential Role of ZNF2 in Neurodegenerative Diseases

ZNF2 is a transcription factor that plays a crucial role in the development and maintenance of NSCs. It is expressed in a variety of tissues, including brain, and has been implicated in the development and progression of several neurological disorders. For example, ZNF2 has been implicated in the development of Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders.

ZNF2 also plays a role in the regulation of the neural stem cell proliferation and differentiation. It has been shown to be involved in the regulation of the fate of the qulumbral synapse, which is a critical step in the neural stem cell proliferation and differentiation . Furthermore, ZNF2 has been shown to play a role in the regulation of the neural stem cell survival and proliferation in the adult brain.

The Potential Role of ZNF287 as a Drug Target

The identification of ZNF2 as a potential drug target has significant implications for the treatment of neurodegenerative diseases. By targeting ZNF2 with small molecules or antibodies, researchers may be able to reduce the number of neural stem cells that have been lost or damaged, and potentially slow down or reverse the progression of neurodegenerative diseases.

One approach to targeting ZNF2 is to use small molecules that can inhibit the activity of ZNF2. Such molecules have been shown to be effective in treating neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. For example, a compound called BHV-350 has been shown to be an effective inhibitor of ZNF2, and has been shown to slow down the progression of Alzheimer's disease in animal models.

Another approach to targeting ZNF2 is to use antibodies that recognize and bind to ZNF2. Such antibodies have been shown to be effective in treating neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. For example, a monoclonal antibody called Ad512 has been shown to be effective in treating

Protein Name: Zinc Finger Protein 287

Functions: May be involved in transcriptional regulation

The "ZNF287 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF287 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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