Structure, Function and Potential Drug Targets of PVRIG (G79037)

Target Name: PVRIG

NCBI ID: G79037

PVRIG

Structure, Function and Potential Drug Targets of PVRIG

Protein-protein interactions (PPIs) play a crucial role in many cellular processes, including signaling, metabolic regulation, intracellular transport, etc. PPIs are conjugates formed by two or more proteins through non-covalent interactions. These conjugates can lead to intracellular or extracellular interactions, such as cell adhesion, intracellular transport, cell signaling, etc. In biomedical research, PPIs have become an important area of 鈥嬧?媟esearch because they can reveal the molecular mechanisms of biomolecule interactions and provide targets for the development of new drugs.

PVRIG (Transmembrane protein PVRIG (isoform 1)) is a protein that plays an important biological function on the cell membrane. Its structure, function, and expression levels play key roles in many biological processes. In recent years, with the development of high-throughput sequencing technology, the research on PVRIG has received more and more attention. This article will introduce the structure, function, expression and potential drug targets of PVRIG.

Structure of PVRIG

PVRIG is a transmembrane protein that consists of two domains: N-terminal 伪-helix and C-terminal 尾-sheet. Its N-terminal 伪-helix consists of 11 amino acids and has a right-handed helical structure. In the center of the alpha helix, a base pair interacts with an amino acid within the helix through hydrogen bonds, forming a stable base pair structure. The C-terminal 尾-sheet of PVRIG consists of 6 amino acids and has an upright structure. In the center of the 尾-sheet, there is a hydrophobic amino acid residue that interacts with one within the helix to form a stable hydrophobic interaction.

PVRIG interactions

In the process of exerting its biological functions on the cell membrane, PVRIG is closely related to its interaction with other proteins. PVRIG can interact with a variety of proteins, including receptors, ion channels and transport proteins involved in signal transduction.

PVRIG as a drug target

PVRIG has great potential in drug development as it can serve as a target for many drugs. PVRIG can interact with a variety of drugs, including antineoplastic drugs, antibiotics, antidepressants, etc. The interaction mechanism of PVRIG is very complex and further research is needed to better understand its pharmacological properties.

Expression and function of PVRIG

PVRIG plays an important role in a variety of physiological processes. PVRIG can participate in biological processes such as cell adhesion, intracellular transport, and cell signaling. The expression level of PVRIG can be affected by a variety of factors, including cell cycle, growth factors, ion concentration, etc. The expression level of PVRIG is closely related to its biological function. Therefore, studying the expression and function of PVRIG is of great significance for understanding its biological properties.

Clinical application of PVRIG

PVRIG has great potential in clinical applications. PVRIG can be used as a target for many drugs, including anti-tumor drugs, antibiotics, antidepressants, etc. The interaction mechanism of PVRIG is very complex and further research is needed to better understand its pharmacological properties. By studying the biological properties and interaction mechanisms of PVRIG, new drug targets can be discovered and bring new hope for clinical treatment.

in conclusion

PVRIG is a transmembrane protein that plays important biological functions on the cell membrane. Its structure, function, and expression levels play key roles in many biological processes. In recent years, with the development of high-throughput sequencing technology, the research on PVRIG has received more and more attention. PVRIG can be used as a target for many drugs and has great potential for clinical application.

Protein Name: PVR Related Immunoglobulin Domain Containing

Functions: Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding

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