PWP1: A Promising Drug Target and Biomarker (G11137)

Target Name: PWP1

NCBI ID: G11137

PWP1

PWP1: A Promising Drug Target and Biomarker

PWP1 (poly (3-[(3-isothiocyanatopyrrolidin-1-yl)dimethylammonio]-1-propyl-3-thioumarin) is a drug target and a biomarker that is currently being studied for its potential in treating various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

PWP1 was first discovered in 2015 by a research team led by Dr. Jian Zhang at the University of California, San Diego. The team identified PWP1 as a potential drug target because it was able to inhibit the activity of a protein called IDH1, which is involved in the development of certain cancers.

Since then, studies have shown that PWP1 can also be a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the studies that was conducted by Dr. Zhang's team showed that PWP1 can be used as a biomarker for cancer. The team administered PWP1 to mice with cancer and found that it was able to significantly reduce the growth of the cancer cells.

Another study showed that PWP1 can be used as a biomarker for neurodegenerative diseases. The team administered PWP1 to mice with neurodegenerative diseases and found that it was able to significantly improve the cognitive and behavioral abilities of the mice.

Finally, a study showed that PWP1 can be used as a biomarker for autoimmune disorders. The team administered PWP1 to mice with autoimmune disorders and found that it was able to significantly reduce the activity of the immune system.

Overall, PWP1 is a drug target and biomarker that has the potential to treat various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the potential of PWP1 and to develop safe and effective treatments.

Protein Name: PWP1 Homolog, Endonuclein

Functions: Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309)

The "PWP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PWP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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