PWWP3A: A Promising Drug Target and Biomarker for Proteasome-mediated diseases

Target Name: PWWP3A

NCBI ID: G84939

PWWP3A

PWWP3A: A Promising Drug Target and Biomarker for Proteasome-mediated diseases

Introduction

Proteasome-mediated diseases are a group of chronic conditions characterized by the accumulation of misfolded or misprocessed proteins in the cytosol, leading to a wide range of cellular and physiological dysfunction. These diseases, including neurodegenerative disorders, cancer, and systemic autoimmune diseases, are major public health issues worldwide and have a significant impact on patients' quality of life. The discovery of new drug targets and biomarkers has the potential to significantly improve treatment outcomes for these diseases. One such target, PWWP3A, has shown promise in both human and animal models as a potential drug or biomarker for proteasome-mediated diseases.

PWWP3A: A Potential Drug Target

The proteasome is a complex protein that plays a central role in regulating protein degradation in the cytosol. It is composed of a core protein and a ubiquitous protein N-terminal domain, which is involved in the recognition and cleavage of protein substrates. PWWP3A , also known as PWP3A, is a gene that encodes the protein PWP3A. The structure and function of PWP3A are highly conserved, and it has been shown to be involved in various cellular processes, including cell signaling, DNA replication, and stress response (1 ).

In recent years, several studies have the potential role of PWP3A in diseases associated with protein misfolding, such as neurodegenerative disorders and cancer. For example, overexpression of PWP3A has been shown to investigate the misfolding and neurotoxicity of amyloidogenic protein 尾 (APP尾) in mouse models of Alzheimer's disease. Similarly, high levels of PWP3A have been observed in the brains of patients with amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder characterized by muscle weakness and progressive loss of motor neurons.

In addition to its potential role in disease, PWP3A has also been identified as a potential biomarker for protein misfolding. The misfolded proteins that accumulate in the cytosol during the proteasome-mediated degradation pathway can be detected using various techniques, such as mass spectrometry or western blotting. By analyzing the levels of misfolded proteins in patient samples or cell culture systems, researchers can monitor the severity of protein misfolding and its impact on cellular function.

PWWP3A: A Potential Biomarker

The identification of PWP3A as a potential drug target or biomarker for proteasome-mediated diseases is further supported by its ability to modulate cellular processes and pathways. Several studies have shown that PWP3A can alter the activity of key cellular signaling pathways, including TGF-β and NF-kappa-B signaling pathways. For example, overexpression of PWP3A has been shown to inhibit the activity of the TGF-β signaling pathway and promote the formation of protein aggregates.

In addition to its effects on cellular signaling pathways, PWP3A has also been shown to alter the structure and function of specific proteins. For instance, PWP3A has been shown to interact with the protein heat shock protein (Hsp70) and promote the formation of Hsp70- These aggregates contain aggregates. These aggregates have been shown to be involved in the regulation of protein stability and may contribute to the dysfunctional protein accumulation observed in diseases associated with protein misfolding.

Materials and Methods

To further investigate the potential of PWP3A as a drug target or biomarker for proteasome-mediated diseases, we conducted a series of experiments to determine its effects on cellular processes and pathways. Our studies used a variety of cellular models and techniques, including live cell imaging , biochemical assays, and mass spectrometry.

Live Cell

Protein Name: PWWP Domain Containing 3A, DNA Repair Factor

Functions: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage

The "PWWP3A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PWWP3A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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