ALDH5A1: Role in Cell Membrane Transport and Alanine/Aspartic Acid Regulation

Target Name: ALDH5A1

NCBI ID: G7915

ALDH5A1

ALDH5A1: Role in Cell Membrane Transport and Alanine/Aspartic Acid Regulation

ALDH5A1 (Alanine/Aspartic Acid D transporting polypeptide synthetase 5A1) is a protein that is expressed in most tissues and cells in the body. It is a member of the superfamily of ATP-binding proteins, known as the A subfamily. ALDH5A1 is involved in the transport of a variety of molecules across cell membranes, including proteins, nucleic acids, and small molecules.

One of the unique features of ALDH5A1 is its role in the synthesis of the amino acid alanine. Alanine is a critical molecule that is involved in many cellular processes, including the regulation of pH and the detoxification of harmful substances. The ability of ALDH5A1 to transport alanine across cell membranes makes it an attractive target for drug development.

In addition to its role in alanine synthesis, ALDH5A1 is also involved in the transport of other molecules across cell membranes. For example, it is a critical regulator of the transport of the amino acid aspartic acid across the cell membrane. Aspartic acid is a regulatory molecule that is involved in many cellular processes, including the regulation of protein structure and function.

The importance of ALDH5A1 in the regulation of aspartic acid transport is supported by the fact that genetic variants in the ALDH5A1 gene have been associated with a variety of diseases, including xenon aortic arch hypoxia (XAOH), a serious congenital disorder that is characterized by a lack of oxygen to the brain. XAOH is caused by a deficiency in the ALDH5A1 gene, which results in a lack of ability to transport aspartic acid across the cell membrane.

The role of ALDH5A1 in the regulation of aspartic acid transport is also of interest in the context of another disease, alkaline phosphatase hypoplasia (APH). APH is a genetic disorder that is characterized by a lack of function in the enzyme alkaline phosphatase. Alkaline phosphatase is a critical enzyme that is involved in the regulation of many cellular processes, including the regulation of bone growth and the detoxification of harmful substances. The lack of function in the alkaline phosphatase enzyme is associated with a variety of symptoms, including bone pain and muscle weakness.

The role of ALDH5A1 in the regulation of aspartic acid transport is also of interest in the context of other diseases, including aging. As we age, the ability of cells to synthesize proteins and other molecules is reduced, which can result in a variety of age -related diseases. The role of ALDH5A1 in the regulation of aspartic acid transport is of particular interest in the context of aging, as it may be involved in the regulation of the transport of nutrients and other molecules across cell membranes.

In conclusion, ALDH5A1 is a protein that is involved in the transport of a variety of molecules across cell membranes, including proteins, nucleic acids, and small molecules. Its role in the regulation of alanine and aspartic acid transport is of particular interest in the context of drug development and the regulation of aging. Further research is needed to fully understand the role of ALDH5A1 in these processes.

Protein Name: Aldehyde Dehydrogenase 5 Family Member A1

Functions: Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)

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