ALKBH5: A Potential Drug Target and Biomarker for ALKylated DNA Repair in Cancer

Target Name: ALKBH5

NCBI ID: G54890

ALKBH5

ALKBH5: A Potential Drug Target and Biomarker for ALKylated DNA Repair in Cancer

DNA damage repair is a crucial cellular process that ensures the stability and integrity of genetic information. DNA repair proteins, such as ALKBH5 (Alkylated DNA repair protein alkB homolog 5), play a vital role in preventing the accumulation of DNA mutations that can lead to the development of cancer. In this article, we will explore the potential drug target and biomarker properties of ALKBH5, highlighting its involvement in the regulation of alkylated DNA repair and its potential as a therapeutic approach for cancer treatment.

Potential Drug Target and Biomarker Properties of ALKBH5

ALKBH5 is a member of the BH domain family, which is known for their role in DNA repair and other cellular processes. The BH domain is a conserved region that is present in various proteins, including DNA repair proteins. The ability of these proteins to repair DNA damage makes them potential drug targets for cancer treatment.

One of the key functions of ALKBH5 is its role in alkylated DNA repair. Alkylated DNA is formed when DNA is exposed to environmental stressors, such as UV radiation, radiation, or chemical mutagens. These stressors can cause the formation of reactive oxygen species (ROS), which can damage DNA and lead to the development of mutations.

ALKBH5 plays a crucial role in repairing these damaged DNA molecules by ensuring the presence of specific repair factors. These repair factors include base excision repair (BER), which involves the removal of a damaged base from the double helix, and homologous recombination (HCR), which involves the replacement of a damaged base with a correctly complementary base.

ALKBH5 is also involved in the regulation of DNA repair efficiency, as well as the cell cycle. It has been shown to play a role in the G1 checkpoint, which is a critical regulatory process that ensures the cell enters a growth-checking state after periods of growth. During the G1 checkpoint, ALKBH5 helps to ensure that the cell has enough repair factors available for DNA repair during the S phase of the cell cycle.

In addition to its role in DNA repair, ALKBH5 has also been shown to have potential as a biomarker for cancer. The accumulation of alkylated DNA in cancer cells is a hallmark of cancer progression, and it is a target for many therapeutic approaches. ALKBH5 has been shown to be expressed in various types of cancer, including breast, ovarian, and colorectal cancers.

Furthermore, ALKBH5 has been shown to be a potential drug target for cancer treatment. Several studies have shown that inhibition of ALKBH5 has led to improved outcomes in cancer patients, including reduced tumor growth and increased survival. These results suggest that ALKBH5 may be a valuable target for cancer treatment.

Conclusion

In conclusion, ALKBH5 is a protein that plays a crucial role in the regulation of alkylated DNA repair and has the potential as a drug target and biomarker for cancer treatment. Its involvement in the repair of damaged DNA molecules and its role in the regulation of DNA repair efficiency make it an attractive target for cancer therapeutic approaches. Further research is needed to fully understand the mechanisms of ALKBH5's role in cancer and to develop effective treatments.

Protein Name: AlkB Homolog 5, RNA Demethylase

Functions: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24489119, PubMed:24616105, PubMed:24778178). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity)

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