ALOXE3: A Potential Drug Target and Biomarker (G59344)

Target Name: ALOXE3

NCBI ID: G59344

ALOXE3

ALOXE3: A Potential Drug Target and Biomarker

ALOXE3 (Arachidonate Lipoxygenase 3, transcript variant 2) is a gene that encodes a protein involved in the production of arachidonic acid, a hormone and signaling molecule in the body. Mutations in the ALOXE3 gene have been linked to various diseases, including cardiovascular, neurodegenerative, and autoimmune disorders. The search for new drug targets and biomarkers has led to the exploration of ALOXE3 as a potential drug target and biomarker.

Diseases and Their Relationship to ALOXE3

ALOXE3 mutations have been implicated in the development and progression of various diseases. One of the well-known diseases associated with ALOXE3 mutations is cardiovascular disease. In individuals with mutations in the ALOXE3 gene, levels of arachidonic acid are increased, leading to the production of pro-inflammatory cytokines and the start of an inflammatory response. This increase in arachidonic acid has been linked to the development of atherosclerosis, an underlying cause of cardiovascular disease.

Another disease associated with ALOXE3 mutations is neurodegenerative disorders. ALOXE3 has been shown to participate in the production of pro-inflammatory cytokines in the brain, which contribute to the development of neurodegenerative disorders.

Autoimmune Disorders

ALOXE3 mutations have also been implicated in the development of autoimmune disorders. The production of arachidonic acid by the immune system is a well-established process in the immune response. However, when this process becomes uncontrolled or dysregulated, it can contribute to the development of autoimmune disorders.

Molecular Mechanisms

The ALOXE3 gene encodes a protein involved in the production of arachidonic acid from its precursor, 12-lipoxygenase (12-LO). 12-LO is a potent enzyme that converts arachidonic acid to 12-hydroxy-arachidonic acid (12-OH-AA), which is then converted to arachidonic acid by ALOXE3.

The ALOXE3 gene has four splice variants, each with a different exon number. The most abundant splice variant is transcript variant 2 (ALOXE3-2), which encodes a protein with 119 amino acid residues. The remaining splice variants encode proteins with different lengths of amino acids.

Expression and Function

Expression of ALOXE3 has been shown to be involved in various cellular processes, including cell signaling, inflammation, and stress responses. ALOXE3 is a cytoplasmic protein that is primarily expressed in the cytoplasm of eukaryotic cells. It is also known to be involved in the production of pro-inflammatory cytokines, as mentioned earlier.

Furthermore, ALOXE3 has been shown to be involved in the regulation of cellular processes, including cell growth, apoptosis, and inflammation. ALOXE3 has been shown to play a role in the regulation of cell cycle progression, cell apoptosis, and the production of pro-inflammatory cytokines.

Drug Targets and Biomarkers

The potential drug targets for ALOXE3 are based on its involvement in the production of pro-inflammatory cytokines and its role in various cellular processes. Several drug targets have been identified for ALOXE3, including inhibition of arachidonic acid synthesis, modulation of arachidonic acid levels, and modulation of cellular signaling pathways.

In addition to drug targets, ALOXE3 has also been identified as a potential biomarker for various diseases, including cardiovascular disease, neurodegenerative disorders, and autoimmune disorders. The production of arachidonic acid is increased in individuals with mutations in the

Protein Name: Arachidonate Lipoxygenase 3

Functions: Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity (PubMed:12881489, PubMed:17045234, PubMed:20921226, PubMed:20923767). The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones (PubMed:12881489, PubMed:17045234, PubMed:20923767). In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides (PubMed:20921226). In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins (PubMed:21558561). Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss (PubMed:21558561). In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites (PubMed:21558561). Also plays a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG (By similarity). Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia (By similarity)

The "ALOXE3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ALOXE3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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