Understanding The Role Of?-Mannosidase in Human Disease (P5829)

Target Name: alpha-Mannosidase

NCBI ID: P5829

alpha-Mannosidase

Other Name(s): a-D-mannoside mannohydrolase

Understanding The Role Of?-Mannosidase in Human Disease

Alpha-mannosidase (伪-mannosidase or a-D-mannoside mannohydrolase) is a enzyme that is involved in the breakdown of mannose, a type of sugar found in many plants and animals. This enzyme is a key player in the metabolism of cellulose and is present in many different organisms, including humans. However, its role in the human body is not well understood, and it is potential drug target or biomarker.

伪-mannosidase is a member of the glycoside hydrolase family 12 (GH12) and is classified as a nonspecific subtype. This subtype is characterized by the presence of a unique catalytic mechanism that involves the transfer of a mannose molecule from the substrate to the enzyme's active site. This reaction is reversible and allows for the cleavage of mannose by the enzyme.

Despite its importance in the metabolism of cellulose, 伪-mannosidase is not widely studied, and its role in human disease is not well understood. There are only a few studies that have investigated the effects of 伪-mannosidase inhibitors on human diseases, and these studies have shown that these compounds have potential therapeutic benefits.

One of the potential therapeutic benefits of 伪-mannosidase inhibitors is their ability to slow down or inhibit the progression of diseases caused by the build-up of too much mannose in the body. For example, some studies have shown that 伪-mannosidase inhibitors can reduce the formation of beta-mannosidose in the brains of mice with Alzheimer's disease, a condition that is characterized by the build-up of beta-mannosidose.

Another potential therapeutic benefit of 伪-mannosidase inhibitors is their ability to improve the quality of life in individuals with certain diseases. For example, some studies have shown that 伪-mannosidase inhibitors can reduce the symptoms of parkinson's disease, a condition that is characterized by the loss of motor control.

In addition to their potential therapeutic benefits, 伪-mannosidase inhibitors are also potential biomarkers for the diagnosis and monitoring of certain diseases. For example, some studies have shown that 伪-mannosidase inhibitors can be used to diagnose Parkinson's disease by analyzing the levels of 伪-mannosidase in brain tissue.

Overall, the study of 伪-mannosidase is an important area of research, as its role in the metabolism of cellulose and its potential therapeutic and biomarker benefits are being explored. Further research is needed to fully understand the role of 伪-mannosidase in the body and its potential as a drug target or biomarker.

Protein Name: Alpha-Mannosidase (nonspecified Subtype)

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