AMBP as a Drug Target: Unlocking the Potential of Protein AMBP

Target Name: AMBP

NCBI ID: G259

AMBP

AMBP as a Drug Target: Unlocking the Potential of Protein AMBP

AMBP (AMyloid-Beta Plasma Protein) is a protein that is expressed in high levels in the blood plasma of individuals with Alzheimer's disease (AD). It is a potential drug target and biomarker for the disease, which has a significant impact on the lives of millions of people worldwide. In this article, we will explore the potential of AMBP as a drug target and biomarker in the context of Alzheimer's disease.

AMBP as a Drug Target

AMBP has been identified as a potential drug target due to its unique structure and its ability to interact with various molecules. AMBP is a transmembrane protein that consists of four regions: a N-terminus, a T-terminus, a middle region, and an C-terminus. It has a calculated molecular weight of 18 kDa and a calculated pI of 9.6. AMBP is highly conserved and has been shown to have similar structures in various species, including humans.

One of the key features that makes AMBP a promising drug target is its ability to interact with various proteins, including beta-amyloid peptides. Beta-amyloid peptides are a hallmark of AD and have been shown to contribute to the development and progression of the disease.AMBP has been shown to interact with beta-amyloid peptides, which may explain its potential as a drug target.

AMBP as a Biomarker

AMBP has also been identified as a potential biomarker for AD. The use of AMBP as a biomarker may have several advantages over other biomarkers, such as ease of collection and high sensitivity.AMBP is a protein that is expressed in high levels in the blood plasma of individuals with Alzheimer's disease, making it a potential biomarker for the disease.

AMBP has been shown to have decreased levels in individuals with AD compared to age-matched individuals. This suggests that AMBP may be a useful biomarker for the disease. Additionally, AMBP has been shown to have a correlation with the levels of beta-amyloid peptides in the brain, which may further support its use as a biomarker for AD.

Conclusion

AMBP is a protein that has potential as a drug target and biomarker for Alzheimer's disease. Its unique structure and ability to interact with various molecules make it a promising candidate for drug development. Further research is needed to fully understand the potential of AMBP as a drug target and biomarker for AD.

Protein Name: Alpha-1-microglobulin/bikunin Precursor

Functions: Antioxidant and tissue repair protein with reductase, heme-binding and radical-scavenging activities. Removes and protects against harmful oxidants and repairs macromolecules in intravascular and extravascular spaces and in intracellular compartments (PubMed:11877257, PubMed:15683711, PubMed:22096585, PubMed:23157686, PubMed:23642167, PubMed:25698971, PubMed:32823731, PubMed:32092412). Intravascularly, plays a regulatory role in red cell homeostasis by preventing heme- and reactive oxygen species-induced cell damage. Binds and degrades free heme to protect fetal and adult red blood cells from hemolysis (PubMed:11877257, PubMed:32092412). Reduces extracellular methemoglobin, a Fe3+ (ferric) form of hemoglobin that cannot bind oxygen, back to the Fe2+ (ferrous) form deoxyhemoglobin, which has oxygen-carrying potential (PubMed:15683711). Upon acute inflammation, inhibits oxidation of low-density lipoprotein particles by MPO and limits vascular damage (PubMed:25698971). Extravascularly, protects from oxidation products formed on extracellular matrix structures and cell membranes. Catalyzes the reduction of carbonyl groups on oxidized collagen fibers and preserves cellular and extracellular matrix ultrastructures (PubMed:23642167, PubMed:22096585). Importantly, counteracts the oxidative damage at blood-placenta interface, preventing leakage of free fetal hemoglobin into the maternal circulation (PubMed:21356557). Intracellularly, has a role in maintaining mitochondrial redox homeostasis. Bound to complex I of the respiratory chain of mitochondria, may scavenge free radicals and preserve mitochondrial ATP synthesis. Protects renal tubule epithelial cells from heme-induced oxidative damage to mitochondria (PubMed:23157686, PubMed:32823731). Reduces cytochrome c from Fe3+ (ferric) to the Fe2+ (ferrous) state through formation of superoxide anion radicals in the presence of ascorbate or NADH/NADPH electron donor cofactors, ascorbate being the preferred cofactor (PubMed:15683711). Has a chaperone role in facilitating the correct folding of bikunin in the endoplasmic reticulum compartment (By similarity)

The "AMBP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AMBP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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