SUV39H2: A Potential Drug Target and Biomarker (G79723)

Target Name: SUV39H2

NCBI ID: G79723

SUV39H2

SUV39H2: A Potential Drug Target and Biomarker

Suv39H2 is a gene that encodes for a protein known as SUV39H2. This protein is a key regulator of microRNA (miRNA) levels, which are small non-coding RNAs that play a crucial role in post-transcriptional gene regulation. SUV39H2 has been shown to regulate the levels of miRNA-181c, a miRNA that has been linked to a variety of cellular processes, including cell growth, differentiation, and programmed cell death.

The discovery of SUV39H2 as a potential drug target and biomarker has significant implications for the development of new treatments for a variety of diseases. By targeting SUV39H2 with small molecules, researchers may be able to disrupt its regulation of miRNA levels and improve the effectiveness of current therapies.

Current Theories

Several current theories have been proposed to explain how SUV39H2 functions as a regulator of miRNA levels. One theory suggests that SUV39H2 may act as a negative regulator of the miRNA-181c gene, by binding to its mRNA and preventing it from being translated into protein. Another theory suggests that SUV39H2 may act as a positive regulator of the miRNA-181c gene, by binding to its miRNA and promoting its translation into protein.

In addition to its potential role as a regulator of miRNA levels, SUV39H2 has also been shown to play a role in the development and progression of several diseases, including cancer. For example, studies have shown that SUV39H2 is often overexpressed in cancer cells, and that inhibiting its activity may be an effective way to treat cancer.

Drug Development

Several small molecules have been shown to interact with SUV39H2 and may be potential drug candidates. One class of small molecules that has been shown to interact with SUV39H2 is the DNA damage-inducible transcription factor DAF-16, which is a protein that is highly expressed in response to DNA damage. Studies have shown that DAF-16 can bind to SUV39H2 and that this interaction may play a role in the regulation of miRNA levels.

Another class of small molecules that has been shown to interact with SUV39H2 is the PI3K/AKT signaling pathway, which is a complex that regulates cell survival and proliferation. Studies have shown that SUV39H2 can interact with the protein Pyknot, which is a key regulator of the PI3K/AKT signaling pathway. This interaction may play a role in the regulation of miRNA levels and the development of cancer.

Conclusion

Suv39H2 is a gene that encodes for a protein that has significant implications as a potential drug target and biomarker. Its regulation of miRNA levels and its role in the development and progression of cancer make it an attractive target for small molecule inhibitors. Further research is needed to fully understand the mechanisms of SUV39H2 as a drug target and biomarker.

Protein Name: SUV39H2 Histone Lysine Methyltransferase

Functions: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation

The "SUV39H2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SUV39H2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets