SYT1: A Potential Drug Target and Biomarker for Neuronal Communication

Target Name: SYT1

NCBI ID: G6857

SYT1

SYT1: A Potential Drug Target and Biomarker for Neuronal Communication

Abstract:

SYNT1, or synaptotagmin 1, is a protein that plays a critical role in the communication of neurons in the central nervous system. Scientific research shows that SYNT1 plays a crucial role in synaptic transmission between neurons. However, the abnormal expression of SYNT1 in neurodegenerative diseases has also attracted attention. This article will explore the role of SYNT1 in neurodegenerative diseases and its potential as a potential drug target and biomarker.

introduction:

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, etc. are a major health threat to the elderly and intellectuals. The main characteristics of these diseases are neuronal loss and abnormal neural circuits. During neuron loss, the expression of the SYNT1 gene changes. The protein encoded by the SYNT1 gene, synaptotagmin 1 (SYNT1), is a protein related to synaptic transmission in neurons. Studies have shown that abnormal expression of SYNT1 is closely related to the occurrence and development of neurodegenerative diseases. Therefore, SYNT1 has become a popular research target in the field of neurodegenerative diseases. This article will start from the role of SYNT1 in neuronal synaptic transmission and explore its potential as a drug target and biomarker.

The role of SYNT1 in neuronal synaptic transmission:

SYNT1 is a key protein in synaptic transmission between neurons. Between neurons, presynaptic neurons release neurotransmitters, which act on postsynaptic neurons to complete the transmission of information. SYNT1 plays a key mediating role between presynaptic and postsynaptic neurons.

First, SYNT1 plays an important role in presynaptic neurons. Research shows that SYNT1 can bind to receptors on neuron axon terminals, thereby affecting the speed and efficiency of neuronal axon terminals to release neurotransmitters. In addition, SYNT1 can also regulate the synaptic connection between presynaptic neurons and postsynaptic neurons, thereby affecting the transmission of information.

Secondly, SYNT1 also plays an important role in postsynaptic neurons. Research shows that SYNT1 can bind to receptors on neuron axon terminals, thereby promoting the release of neurotransmitters from neuron axon terminals. This released neurotransmitter can act on the axon terminal of the next neuron to further complete the transmission of information.

In addition, SYNT1 can also regulate synaptic connections between presynaptic and postsynaptic neurons. Research shows that SYNT1 can affect the interaction between neuron axon terminals and the postsynaptic membrane, thereby regulating the transmission of information.

The role of SYNT1 in neurodegenerative diseases:

Abnormal expression of SYNT1 in neurodegenerative diseases has become a popular research area. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, etc. are a major health threat to the elderly and intellectuals. The main characteristics of these diseases are neuronal loss and abnormal neural circuits.

Studies have found that abnormal expression of SYNT1 is closely related to the occurrence and development of neurodegenerative diseases. For example, studies have shown that overexpression of SYNT1 is closely related to the occurrence of Alzheimer's disease. In addition, abnormal expression of SYNT1 can also lead to abnormal neuronal circuits and further aggravate neurodegenerative diseases.

Protein Name: Synaptotagmin 1

Functions: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003)

The "SYT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SYT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets