SYCE2: A Protein Involved in Cell Growth, Differentiation and Disease

Target Name: SYCE2

NCBI ID: G256126

SYCE2

Other Name(s): CESC1 | Central element synaptonemal complex protein 1 | synaptonemal complex central element protein 2 | SYCE2_HUMAN | Synaptonemal complex central element protein 2

SYCE2: A Protein Involved in Cell Growth, Differentiation and Disease

SYCE2 (Sorbitol-conjugated Estrogen-2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and bones. It is a key regulator of cell growth and differentiation and has been implicated in a number of diseases, including cancer.

One of the key functions of SYCE2 is its role as a negative regulator of the cell cycle. It helps to control the entry of cells into the cell cycle by inhibiting the activity of the protein kinase cyclin D1. This protein plays a crucial role in regulating the cell cycle by controlling the movement of chromosomes into the center of the cell.

In addition to its role in regulating the cell cycle, SYCE2 is also involved in a number of other cellular processes that are important for normal development and maintenance. For example, it is involved in the regulation of cell adhesion, as well as in the development and maintenance of tissues such as bones and heart.

SYCE2 has also been shown to play a role in the regulation of inflammation. It has been shown to be involved in the regulation of the immune response and has been implicated in the development of a number of inflammatory diseases, including cancer.

In addition to its role in cell regulation and inflammation, SYCE2 has also been shown to play a role in the development of certain diseases. For example, it has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.

Given its involvement in a number of important cellular processes, SYCE2 has generated a lot of interest among researchers as a potential drug target or biomarker. Studies have shown that blocking the activity of SYCE2 has the potential to treat a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug or biomarker, SYCE2 is also of interest to researchers because of its unique structure and biology. Unlike many other proteins, SYCE2 is not a typical transcription factor, meaning it does not interact with DNA to regulate gene expression. Instead, it is a negative regulator of the cell cycle that works by inhibiting the activity of the protein kinase cyclin D1.

This unique structure and biology make SYCE2 an unusual target for drug development. Because it does not have a typical binding site for drugs, researchers have had to develop novel approaches to target it. One approach is to use small molecules that can inhibit the activity of SYCE2, such as those that bind to its active site. Another approach is to use antibodies that can selectively target SYCE2 and prevent it from interacting with its binding partners.

While the development of drugs that target SYCE2 is still in its early stages, it has the potential to be a valuable tool for the treatment of a number of diseases. Studies are ongoing to determine the effectiveness and safety of these drugs, and further research is being conducted to better understand the underlying biology of SYCE2 and its role in disease.

In conclusion, SYCE2 is a protein that is involved in a number of important cellular processes and has been implicated in a number of diseases. Its unique structure and biology make it an unusual target for drug development, and research is ongoing to determine its potential as a treatment for a variety of conditions. While the development of drugs that target SYCE2 is still in its early stages, it has the potential to be a valuable tool for the treatment of a number of diseases.

Protein Name: Synaptonemal Complex Central Element Protein 2

Functions: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination (By similarity)

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