SYMPK: A Protein Involved in Neurological Disorders (G8189)

Target Name: SYMPK

NCBI ID: G8189

SYMPK

SYMPK: A Protein Involved in Neurological Disorders

Synaptotoxin (SYMPK), also known as Pt1, is a protein that is expressed in the central nervous system (CNS) and has been shown to play a role in the development and progression of several neurological disorders, including Alzheimer's disease, Parkinson's disease, and chronic pain.

SYMPK is a transmembrane protein that is expressed in the dopamine-producing neurons of the CNS. It is composed of four transmembrane domains (TMDs) and a cytoplasmic tail. The TMDs contain a unique catalytic core that is involved in the regulation of intracellular signaling pathways, including the cAMP/cGMP signaling pathway.

SYMPK is shown to play a role in the regulation of intracellular signaling pathways that are involved in the development and progression of neurological disorders. For example, studies have shown that SYMPK is involved in the regulation of neurotransmitter release from dopamine-producing neurons, and that it plays a role in the development of neurodegeneration in models of Alzheimer's disease and Parkinson's disease.

In addition to its role in neurotransmission, SYMPK is also shown to play a role in the regulation of cellular signaling pathways that are involved in pain perception and chronic pain. For example, studies have shown that SYMPK is involved in the regulation of pain signaling in response to stimuli that are associated with chronic pain.

Given the potential role of SYMPK in the development and progression of neurological disorders, it is an attractive target for drug development. Researchers are currently working to develop small molecules that can inhibit the activity of SYMPK and prevent its development in neurodegenerative diseases. These efforts are being driven by a growing understanding of the underlying mechanisms that are involved in the regulation of SYMPK function and its role in the development of neurodegenerative diseases.

In conclusion, SYMPK is a protein that is expressed in the CNS and is involved in the regulation of intracellular signaling pathways that are involved in the development and progression of several neurological disorders. Its role in these processes makes it an attractive target for drug development, and researchers are currently working to develop small molecules that can inhibit its activity and prevent its development in neurodegenerative diseases.

Protein Name: Symplekin Scaffold Protein

Functions: Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity

The "SYMPK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SYMPK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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