SYDE1: A Potential Drug Target and Biomarker for GTPase-Activating Proteins

Target Name: SYDE1

NCBI ID: G85360

SYDE1

SYDE1: A Potential Drug Target and Biomarker for GTPase-Activating Proteins

Guanosine triphosphate (GTP) is a crucial molecule in intracellular signaling, where it acts as a signal transducer to regulate various cellular processes. GTPase-activating proteins (GAPs) are a family of proteins that play a central role in the regulation of GTP signaling. Among the GAPs, SYDE1 (Rho GTPase-activating protein SYDE1) is a well-known protein that has attracted significant interest due to its unique function and potential as a drug target or biomarker.

SYDE1 is a 21 kDa protein that is expressed in various tissues and cells, including muscle, heart, and brain. Its function is to regulate the activity of the Rho GTPase, which is a protein that catalyzes the conversion of GTP to GDP at its active site. The Rho GTPase is a key regulator of many cellular processes, including cell growth, differentiation, and survival. The activity of Rho GTPase is regulated by various guanosine triphosphate-binding proteins (GTP-BPs), which include GAPs, APs, and CPs.

SYDE1 is a GAP that can activate the Rho GTPase in a dose-dependent manner. Studies have shown that SYDE1 can increase the activity of Rho GTPase, leading to increased protein production and cell proliferation. Additionally, SYDE1 can also regulate the degradation of Rho GTPase, which may contribute to the persistence of Rho GTPase activity in cells.

SYDE1 has been shown to play a role in various cellular processes, including cell signaling, cell cycle regulation, and tissue repair. For example, studies have shown that SYDE1 is involved in the regulation of muscle cell growth, differentiation, and survival. Additionally, SYDE1 has also been shown to play a role in the regulation of neural cell survival and plasticity.

SYDE1 has also been shown to be a potential drug target. The Rho GTPase is a key regulator of many cellular processes, and targeting Rho GTPase activity may be a promising strategy for the development of therapeutic agents for various diseases. Studies have shown that SYDE1 is a good candidate for targeting with small molecules, including inhibitors of the Rho GTPase.

In addition to its potential as a drug target, SYDE1 has also been shown to be a potential biomarker for various diseases. The Rho GTPase is a key regulator of many cellular processes, and its activity can be affected by various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. The activity of Rho GTPase can be used as a biomarker to diagnose and monitor these diseases.

SYDE1 has also been shown to play a role in the regulation of cellular signaling pathways. Studies have shown that SYDE1 is involved in the regulation of several cellular signaling pathways, including the regulation of cell growth, apoptosis, and autophagy. Additionally, SYDE1 has also been shown to play a role in the regulation of cell cycle progression, and its activity can be affected by various cellular factors, including the level of cyclin D1.

In conclusion, SYDE1 is a well-known protein that has the potential to be a drug target or biomarker for various diseases. Its function as a GAP that can activate the Rho GTPase and its involvement in various cellular processes make it an attractive target for small molecules. Additionally, its potential as a biomarker for diseases that involve the regulation of Rho GTPase activity makes it an attractive candidate for diagnostic and therapeutic applications. Further research is needed to fully understand the role of SYDE1 in cellular signaling pathways and its potential as a drug target or biomarker.

Protein Name: Synapse Defective Rho GTPase Homolog 1

Functions: GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 (PubMed:27917469)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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