Introduction to SYNE4 (G163183)

Target Name: SYNE4

NCBI ID: G163183

SYNE4

Introduction to SYNE4
SYNE4, a Promising Drug Target in Cancer Therapeutics

The field of cancer therapeutics has witnessed significant advancements in recent years, leading to improved patient outcomes and survival rates. One important aspect of this progress is the identification and validation of specific drug targets or biomarkers that can be utilized for the development of targeted therapies. Among these targets, SYNE4 has emerged as a promising candidate for further exploration. This article will delve into the role of SYNE4 as a drug target (or biomarker) and its potential implications in cancer research and treatment.

What is SYNE4?
SYNE4, also known as spectrin repeat-containing nuclear envelope protein 4, is a gene encoding a specific protein that plays a crucial role in nuclear envelope assembly and organization. It belongs to a larger family of proteins known as the spectrin repeat-containing nuclear envelope (SYNE) family. SYNE4 is primarily located in the nuclear envelope, which separates the nucleus from the cytoplasm in eukaryotic cells. This positioning highlights its significance in maintaining the structural integrity and functional dynamics of the nuclear envelope.

Syne Proteins and Cellular Processes:
SYNE family proteins are instrumental in various cellular processes, including nuclear positioning and nuclear migration. They play crucial roles in maintaining the structure and stability of the nucleus, as well as mediating interactions between the nuclear envelope and the cytoskeleton. These functions are essential for fundamental cellular processes such as cell division, cell migration, and mechanotransduction.

The Role of SYNE4 as a Drug Target:
The dysregulation of SYNE4 has been implicated in various pathological conditions, including cancer. Research has shown that aberrant expression of SYNE4 is associated with the development and progression of several types of cancer, such as breast, ovarian, and prostate cancer. This mounting evidence suggests that SYNE4 could serve as an attractive drug target for cancer therapeutics.

Potential Therapeutic Strategies Targeting SYNE4:
Given its relevance in cancer biology, targeting SYNE4 could hold promise for the development of novel therapeutic strategies. One approach is to develop small molecule inhibitors that selectively interfere with the functions of SYNE4. These inhibitors could disrupt the assembly of the nuclear envelope or inhibit the interactions between SYNE4 and other proteins involved in cancer progression. Another strategy involves the use of gene therapies to modify the expression or activity of SYNE4, either by silencing it or restoring normal function.

Challenges and Limitations:
Although SYNE4 appears to be a promising drug target, there are several challenges and limitations that need to be addressed. First, the development of selective inhibitors that specifically target SYNE4 without affecting other essential nuclear envelope proteins is a formidable task. Second, the delivery of potential therapeutic agents to the nuclear envelope is technically challenging due to the physical and structural barriers posed by the double membrane. Third, further research is required to fully elucidate the molecular mechanisms by which SYNE4 contributes to cancer progression to inform the design of effective therapeutic interventions.

Biomarker Potential of SYNE4:
In addition to being a drug target, SYNE4 also holds potential as a biomarker for cancer diagnosis, prognosis, and personalized treatment. Studies have demonstrated correlations between SYNE4 expression levels and clinical outcomes, including survival rates and response to specific therapies. Therefore, determining the expression status of SYNE4 in patients could provide valuable information for tailoring treatment strategies and predicting individual responses to various therapeutic interventions.

Conclusion:
SYNE4, a spectrin repeat-containing nuclear envelope protein, has emerged as a promising drug target and biomarker in cancer research and therapeutics. Its crucial role in nuclear envelope assembly, as well as its aberrant expression in cancer, highlights its potential as a therapeutic target. However, significant challenges still need to be overcome to fully exploit the potential of SYNE4 in cancer treatment. Further research and innovative strategies are required to develop effective inhibitors and delivery methods while deepening our understanding of the molecular mechanisms underlying SYNE4's involvement in cancer development and progression. As the field advances, SYNE4 has the potential to shape the future of personalized cancer therapies and improve patient outcomes.

Protein Name: Spectrin Repeat Containing Nuclear Envelope Family Member 4

Functions: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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