SEM1: A Protein Involved in Cellular Processes and Disease (G7979)

Target Name: SEM1

NCBI ID: G7979

SEM1

SEM1: A Protein Involved in Cellular Processes and Disease

SEM1 (SEM1 26S proteasome subunit) is a protein that is expressed in a variety of cell types, including neurons, muscle cells, and immune cells. It is a key component of the proteasome, a complex machine that breaks down and removes proteins from cells . SEM1 is responsible for the final cleavage of some proteins, and its activity has been linked to a number of cellular processes, including cell division, apoptosis (programmed cell death), and inflammation.

SEM1 is also a potential drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in these conditions has been studied extensively, and several studies have identified potential drug targets based on SEM1 activity.

One of the main targets for SEM1 is the inhibition of its activity by small molecules, such as drugs that can bind to specific SEM1 domains. These drugs have been shown to be effective in treating a variety of diseases, including neurodegenerative disorders, cancer, and autoimmune disorders.

Another potential target for SEM1 is the Blockade of SEM1-mediated autophagy (SMA). SMA is a process by which cells break down and recycle their own damaged or unnecessary proteins, and it is thought to play a role in a number of diseases, including cancer, neurodegenerative disorders, and aging.

SEM1 has also been shown to be involved in the regulation of cellular processes that are important for the development and maintenance of cancer. For example, studies have shown that SEM1 is involved in the regulation of cell cycle progression, which is the process by which cells grow and divide, and that it is a suppressor of the G1-S transition, which is the stage at which cells prepare for cell division.

In addition to its role in cellular processes, SEM1 has also been shown to play a role in the development and progression of certain diseases. For example, studies have shown that SEM1 is involved in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, and that it is a potential therapeutic target for these conditions.

SEM1 has also been shown to be involved in the regulation of cellular immune responses, which are important for the fight against infection and disease. For example, studies have shown that SEM1 is involved in the regulation of T cell development and that it plays a role in the development of autoimmune disorders.

In conclusion, SEM1 is a protein that is involved in a number of cellular processes that are important for the development and maintenance of health. Its activity has been linked to a variety of diseases, including cancer, neurodegenerative disorders, and autoimmune disorders, and it is a potential drug target for these conditions. Further research is needed to fully understand the role of SEM1 in these diseases and to develop effective treatments.

Protein Name: SEM1 26S Proteasome Subunit

Functions: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells

The "SEM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SEM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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