CLMP: A Promising Drug Target and Biomarker for Coxsackie- and Adenovirus Receptor-Like Membrane Protein

Target Name: CLMP

NCBI ID: G79827

CLMP

CLMP: A Promising Drug Target and Biomarker for Coxsackie- and Adenovirus Receptor-Like Membrane Protein

Introduction

Coxsackie- and adenovirus receptor-like membrane protein (CLMP) is a transmembrane protein that plays a crucial role in the immune response and inflammation. It is expressed in various tissues and cell types, including epithelial, endothelial, and immune cells. CLMP functions as a receptor for Coxsackie- and adenovirus (CS&A) virus infection, participating in the immune response to these pathogens.

Recent studies have identified CLMP as a potential drug target and biomarker for various diseases, including cancer, cardiovascular diseases, and neurological disorders. In this article, we will explore the biology and potential therapeutic applications of CLMP in greater detail.

Biogenesis and Expression

CLMP is a 21-kDa protein that consists of an N-terminal cytoplasmic domain, a transmembrane region, and an C-terminal T-cell antigen (TCA) domain. It is expressed in various tissues, including epithelial and endothelial cells, as well as immune cells such as dendritic cells, macrophages, and T cells. The expression of CLMP is regulated by various factors, including DNA replication, cell growth, and cytokine signaling pathways.

Function and Interaction with CS&A Viruses

CS&A viruses are a group of small, double-stranded, negative polarity RNA viruses that can cause a variety of human and animal diseases, including Guillain-Barr茅 syndrome, demyelination, and cancer. These viruses infect cells through their viral envelope, which consists of a lipid-coated surface and a transmembrane protein called VP120.

CLMP is a critical receptor for the entry of CS&A viruses into host cells. Research shows that CLMP plays a crucial role in the recognition and internalization of CS&A virus particles. CLMP interacts with the virus's VP120 protein, allowing the virus to bind to and enter the host cells.

In addition to its role in virus entry, CLMP has also been shown to participate in the immune response to CS&A viruses. Studies have shown that CLMP is involved in the production of antibodies against the virus, as well as the regulation of inflammation and immune cell function.

Potential Therapeutic Applications

The therapeutic potential applications of CLMP are vast and varied. As a drug target, CLMP could be used to treat a variety of diseases that are caused by CS&A viruses or their interactions with the immune system.

1.Cancer

CLMP has been shown to play a role in the development and progression of various cancers, including breast, ovarian, and colorectal cancers. For example, studies have shown that high levels of CLMP are associated with poor prognosis in patients with colorectal cancer. Additionally, CLMP has been shown to promote the growth and metastasis of breast cancer cells.

1. Cardiovascular Diseases

CLMP has also been shown to be involved in the development and progression of cardiovascular diseases. Studies have shown that CLMP is expressed in the endothelium, which is the lining of the blood vessels, and that it plays a role in the regulation of blood vessel diameter and permeability.

1. Neurological Disorders

CLMP is involved in the development and progression of several neurological disorders, including multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Studies have shown that CLMP is involved in the regulation of neurotransmitter signaling and that it plays a role in the development of neurodegeneration.

1. Inflammatory Diseases

CLMP is involved in the regulation of inflammation and immune cell function, and has been shown to play a role in the development and progression of inflammatory diseases such as rheumatoid arthritis and lupus.

Conclusion

In conclusion, CLMP is a protein that plays a crucial role in the immune response and inflammation. Its function as a receptor for CS&A viruses and its involvement in the development and progression of various diseases make it an attractive drug target and biomarker for therapeutic intervention. Further research is needed to fully understand the biology and clinical applications of CLMP, and to develop safe and effective treatments for the various diseases it is involved in.

Protein Name: CXADR Like Membrane Protein

Functions: May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development

The "CLMP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CLMP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets