The H4C9 Protein: A Potential Drug Target (G8294)

Target Name: H4C9

NCBI ID: G8294

H4C9

Other Name(s): H4 histone family, member M | Histone H4 | HIST1H4E | Histone 4 family, member M | histone family member | H4C14 | HIST1H4H | HIST1H4J | translation initiation factor IF-2-like | histone cluster 1, H4i | H4C8 | HIST1H4A | H4_HUMAN | H4M | H4C12 | histone 1, H4i | H4C11 | HIST4H4 | H4 clustered histone 9 | H4C5 | HIST2H4A | HIST2H4B | H4C6 | H4C16 | H4C15 | H4C3 | H4C1 | histone cluster 1 H4 family member i | TEVANED4 | HIST1H4B | H4C4 | H4C13 | HIST1H4D | HIST1H4L | H4FM | H4C2 | HIST1H4F | HIST1H4K | HIST1H4I | HIST1H4C | H4/m | H4-16

The H4C9 Protein: A Potential Drug Target

The H4C9 protein is a member of the histone family and is located in the nucleoplasm of eukaryotic cells. It plays a critical role in the regulation of gene expression, DNA replication, and chromatin stability. The H4C9 protein is also known as H4C9, H4. 1, H4.2, and H4.3, and its function has been extensively studied over the years.

The H4C9 protein is composed of 45 amino acid residues and has a calculated molecular weight of 61.1 kDa. It consists of a single alpha helix and a single beta sheet, with a highly conserved tail region. The protein has a characteristic positively charged interface and is involved in various cellular processes, including DNA replication, transcription, and gene regulation.

One of the most significant functions of the H4C9 protein is its role in DNA replication. The H4C9 protein is essential for the proper formation of the chromatin fiber, which is the essential component of chromosome organization and replication. In DNA replication, the H4C9 protein is involved in the recruitment of the enzyme DNA polymerase to the site of DNA replication. This interaction between the H4C9 protein and DNA polymerase is critical for the efficient and accurate replication of genetic information.

Another function of the H4C9 protein is its role in gene regulation. The H4C9 protein is involved in the regulation of gene expression by controlling the levels of histone modifications on the chromatin. Histone modifications are chemical modifications to the histone proteins that make up the nucleoplasm. They include acetylation, methylation, phosphorylation, and ubiquitination, among others. These modifications play a critical role in regulating gene expression by altering the accessibility of gene promoters and the activity of transcription factors.

The H4C9 protein is also involved in the regulation of DNA replication, specifically in the phase of DNA replication where the double helix is 鈥嬧?媟eplicated. The H4C9 protein has been shown to play a role in the regulation of DNA replication by interacting with the enzyme DNA polymerase.

In addition to its role in DNA replication, the H4C9 protein is also involved in the regulation of gene expression. It has been shown to play a role in the regulation of gene expression by controlling the levels of histone modifications on the chromatin. Histone modifications are chemical modifications to the histone proteins that make up the nucleoplasm. They include acetylation, methylation, phosphorylation, and ubiquitination, among others. These modifications play a critical role in regulating gene expression by altering the accessibility of gene promoters and the activity of transcription factors.

The H4C9 protein is also involved in the regulation of cell division. It has been shown to play a role in the regulation of cell division by controlling the levels of histone modifications on the chromatin. Histone modifications are chemical modifications to the histone proteins that make up the nucleoplasm. They include acetylation, methylation, phosphorylation, and ubiquitination, among others. These modifications play a critical role in regulating cell division by altering the accessibility of gene promoters and the activity of transcription factors.

In conclusion, the H4C9 protein is a critical protein involved in various cellular processes, including DNA replication, gene regulation, and cell division. Its function as a drug target or biomarker is under investigation, with various studies showing its potential as a potential therapeutic agent for various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

The H4C9 protein is a potential drug target due to its involvement in various cellular processes that are affected in various diseases. Its role in DNA replication, gene regulation, and cell division make it a promising target for therapeutic intervention. Further research is needed to fully understand the function of the H4C9 protein as a drug target and to develop effective treatments for various diseases.

Protein Name: H4 Clustered Histone 9

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

The "H4C9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H4C9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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