ZNRF3: Potential Cancer Therapies and Biomarkers (G84133)

Target Name: ZNRF3

NCBI ID: G84133

ZNRF3

ZNRF3: Potential Cancer Therapies and Biomarkers

ZNRF3 (Zinc Finger Nucleotide Repeat-Containing 3) is a protein that is expressed in various tissues of the human body. It is a member of the Zinc Finger Nucleotide Repeat (ZFNR) family, which is a group of proteins that contain a characteristic repeat sequence of nucleotides at their C-terminus. ZNRF3 is highly conserved and has been identified in various cellular processes, including cell signaling, DNA replication, and gene regulation.

One of the unique features of ZNRF3 is its ability to interact with other proteins, particularly with the protein p16INK4a. p16INK4a is a transcription factor that plays a role in cell signaling and is often associated with various diseases, including cancer. ZNRF3 has been shown to physically interact with p16INK4a and can enhance the activity of p16INK4a. This interaction between ZNRF3 and p16INK4a has potential implications for the development of cancer therapies that target this interaction.

Another promising aspect of ZNRF3 is its role in the regulation of DNA replication. DNA replication is a critical process for the growth and development of all living organisms, and it is checkpointed by various proteins, including DNA damage-associated proteins (DAPs). ZNRF3 has been shown to interact with DAPs, including DAP-1, which is a protein that is involved in the repair of DNA damage. This interaction between ZNRF3 and DAP-1 suggests that ZNRF3 may be a drug target or biomarker for diseases that are characterized by disruptions in DNA replication, such as cancer.

ZNRF3 has also been shown to play a role in cell signaling and gene regulation. It has been shown to interact with various transcription factors, including NF-kappa-B, AP-1, and STAT3. These interactions suggest that ZNRF3 may be involved in the regulation of gene expression and that it may be a potential target for drugs that affect cellular signaling pathways.

In conclusion, ZNRF3 is a protein that has been identified in various cellular processes and has been shown to interact with other proteins, including p16INK4a and DAP-1. These interactions suggest that ZNRF3 may be a drug target or biomarker for various diseases, including cancer and diseases characterized by disruptions in DNA replication. Further research is needed to fully understand the role of ZNRF3 in cellular processes and to develop effective therapies that target this protein.

Protein Name: Zinc And Ring Finger 3

Functions: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)

The "ZNRF3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNRF3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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