Protein Kinase-like Protein SGK196: A Promising Drug Target and Biomarker

Target Name: POMK

NCBI ID: G84197

POMK

Protein Kinase-like Protein SGK196: A Promising Drug Target and Biomarker

Introduction

Protein kinase-like protein (PKL) SGK196 is a unique transmembrane protein that plays a crucial role in cell signaling pathways. It is a non-catalytic protein that belongs to the SGK family, which is known for its ability to regulate protein kinases. SGK196 has been shown to play a key role in various cellular processes, including cell adhesion, migration, and survival. As a result, SGK196 has emerged as a promising drug target and biomarker.

During this article, we will discuss the biology and functions of SGK196, its potential as a drug target, and its potential as a biomarker for various diseases.

Biography of SGK196

SGK196 is a 21-kDa protein that is expressed in various tissues and cells. It is primarily localized to the cell surface and plays a role in regulating the activities of other proteins, including tyrosine kinases, phosphatidylinositol (PI) kinases, and Src tyrosine kinases . SGK196 is a non-catalytic protein that contains a catalytic domain, a transmembrane region, and a cytoplasmic tail.

Function and Interaction of SGK196

SGK196 is involved in various cellular processes, including cell adhesion, migration, and survival. It has been shown to play a key role in cell-cell adhesion by regulating the activities of cadherins, a family of transmembrane proteins that are involved in cell-cell adhesion. SGK196 has been shown to regulate the activity of cadherins by phosphorylation and depolyphosphorylation.

SGK196 has also been shown to play a key role in cell migration. It has been shown to regulate the activities of migration-related proteins, including the myosin heads and the microtubules that support the cytoskeleton. the regulation of cell survival by preventing the formation of apoptotic cells.

Potential Drug Target

SGK196 has emerged as a promising drug target due to its involvement in various cellular processes that are associated with various diseases. For example, SGK196 has been shown to be involved in the development and progression of various types of cancer, including breast, lung, and ovarian cancer. It has also been shown to be involved in the regulation of cell adhesion, which is often disrupted in cancer cells.

In addition, SGK196 has been shown to play a key role in the regulation of cell survival, which is often disrupted in cancer cells. This suggests that SGK196 may be a useful drug target for diseases associated with altered cell survival, such as cancer.

Potential Biomarkers

SGK196 has also been shown to be a potential biomarker for various diseases. For example, it has been shown to be involved in the regulation of cell adhesion, which is often disrupted in diseases such as cancer, neurodegenerative diseases, and autoimmune diseases.

In addition, SGK196 has been shown to play a key role in the regulation of cell survival, which is often disrupted in diseases such as cancer, neurodegenerative diseases, and autoimmune diseases. This suggests that SGK196 may be a useful biomarker for diseases associated with altered cell survival.

Conclusion

SGK196 is a unique transmembrane protein that plays a crucial role in cell signaling pathways. It is a non-catalytic protein that belongs to the SGK family and has been shown to play a key role in various cellular processes, including cell adhesion, migration, and survival. As a result, SGK196 has emerged as a promising drug target and biomarker for various diseases. Further research is needed to fully understand the biology and functions of SGK196 and its potential as a drug

Protein Name: Protein O-mannose Kinase

Functions: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif

The "POMK Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POMK comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets