POU4F1: A Drug Target / Disease Biomarker (G5457)

Target Name: POU4F1

NCBI ID: G5457

POU4F1

POU4F1: A Drug Target / Disease Biomarker

POU4F1, also known as heat shock protein 4.1 (Hsp4.1), is a protein that is expressed in a variety of tissues and cells throughout the body. It is a key component of the heat shock response, which is a critical adaptive response of cells to increased temperatures, such as those that occur during exercise or other physical activities.

POU4F1 is a small protein that consists of 21 amino acid residues. It is expressed in a variety of tissues, including muscle, heart, kidney, and brain, and is also found in the cytoplasm of cells. It is involved in a number of different cellular processes, including cell signaling, DNA replication, and protein folding.

One of the most interesting functions of POU4F1 is its role in the heat shock response. When cells are subjected to increased temperatures, POU4F1 helps to maintain the stability of the cell's cytoskeleton and prevent it from breaking down. This is important for the survival of the cell and allows it to continue to function under extreme conditions.

In addition to its role in the heat shock response, POU4F1 is also involved in a number of other cellular processes. For example, it has been shown to be involved in cell signaling, particularly in the regulation of protein kinase signaling. It has also been shown to play a role in the replication of DNA in response to various types of stress, such as UV radiation and chemotherapy.

Despite its importance in a variety of cellular processes, POU4F1 is not yet widely understood or targeted as a drug or biomarker. While there is some research being done to investigate the potential functions of POU4F1, much more research is needed to fully understand its role in the body and how it can be used to treat various diseases.

In conclusion, POU4F1 is a protein that is expressed in a variety of tissues and cells throughout the body. It is involved in a number of different cellular processes, including the heat shock response and DNA replication. While there is some research being done to investigate the potential functions of POU4F1, much more research is needed to fully understand its role in the body and how it can be used to treat various diseases.

Protein Name: POU Class 4 Homeobox 1

Functions: Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site

The "POU4F1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POU4F1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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