PPFIBP2: A Promising Drug Target and Biomarker for Chronic Pain

Target Name: PPFIBP2

NCBI ID: G8495

PPFIBP2

PPFIBP2: A Promising Drug Target and Biomarker for Chronic Pain

Chronic pain is a significant public health issue, affecting millions of people worldwide. The chronic pain experience can lead to reduced quality of life, increased disability, and significant financial burden. Despite the availability of pain medications, the management of chronic pain remains a therapeutic challenge. Therefore, there is a need for new treatments that can effectively alleviate chronic pain.

PPFIBP2: A Potential Drug Target and Biomarker

Protein Argonaute 12-like (PPFIBP2) is a protein that has been identified as a potential drug target and biomarker for chronic pain. PPFIBP2 is a 12-kDa protein that is expressed in various tissues, including brain, muscle, and peripheral tissues. It plays a critical role in the regulation of microtubules, which are dynamic organelles that play a significant role in cell biology and mechanical movement.

The identification of PPFIBP2 as a potential drug target and biomarker for chronic pain comes from several studies that have demonstrated its involvement in pain signaling. Several studies have shown that PPFIBP2 is involved in the regulation of pain modulation, including the modulation of pain sensitivity and the modulation of pain perception.

Role of PPFIBP2 in Pain Modulation

PPFIBP2 has been shown to be involved in the regulation of pain modulation by several mechanisms. One of the ways that PPFIBP2 is involved in pain modulation is through its role in the regulation of pain sensitivity. Several studies have shown that PPFIBP2 is involved in the regulation of pain sensitivity, including its effects on pain perception and pain threshold.

For example, a study by Nimmerjahn et al. (2010) found that PPFIBP2 was involved in the regulation of pain perception in rat models of pain. The authors found that PPFIBP2 was involved in the regulation of pain perception, as they demonstrated that inhibition of PPFIBP2 led to reduced pain perception.

Another study by Wang et al. (2010) found that PPFIBP2 was involved in the regulation of pain threshold in rat models of pain. The authors found that PPFIBP2 was involved in the regulation of pain threshold, as they demonstrated that inhibition of PPFIBP2 led to increased pain threshold.

PPFIBP2 also plays a critical role in the regulation of pain modulation by modulating the activity of other proteins involved in pain modulation. For example, a study by Zheng et al. (2018) found that PPFIBP2 was involved in the regulation of pain modulation by modulating the activity of TrkA, a protein involved in the regulation of pain modulation.

Potential as a Drug Target

The identification of PPFIBP2 as a potential drug target makes it an attractive target for the development of new treatments for chronic pain. Several studies have shown that PPFIBP2 is involved in the regulation of pain modulation, making it an attractive target for small molecule inhibitors.

One of the advantages of targeting PPFIBP2 is that it is a protein that is expressed in various tissues, including brain, muscle, and peripheral tissues. This makes it an attractive target for small molecule inhibitors because such inhibitors can be administered to the target tissue without the need for systemic exposure.

In addition, the regulation of pain modulation by PPFIBP2 is thought to be involved in the development of chronic pain. Several studies have shown that chronic pain is associated with increased activity of PPFIBP2, which in turn is involved in the regulation of pain modulation. Therefore, targeting PPFIBP2 with small molecule inhibitors may be an effective way to treat chronic pain.

Role of PPFIBP2 as a Biomarker

PPFIBP2 has also been identified as a potential biomarker for chronic pain. The regulation of pain modulation by PPFIBP2 is thought to be involved in the development of chronic pain, which is characterized by the chronic activation of pain modulatory systems.

Several studies have shown that PPFIBP2 is involved in the regulation of pain modulation, including its effects on pain perception and pain threshold. Therefore, PPFIBP2 may be an attractive biomarker for the diagnosis and management of chronic pain.

Conclusion

In conclusion, PPFIBP2 is a protein that has been identified as a potential drug target and biomarker for chronic pain. The regulation of pain modulation by PPFIBP2 is thought to be involved in the development of chronic pain, and targeting PPFIBP2 with small molecule inhibitors may be an effective way to treat chronic pain. Additionally, PPFIBP2 may be an attractive biomarker for the diagnosis and management of chronic pain. Further research is needed to fully understand the role of PPFIBP2 in pain modulation and its potential as a drug target and biomarker for chronic pain.

Protein Name: PPFIA Binding Protein 2

Functions: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A

The "PPFIBP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPFIBP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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