PPARA: A Drug Target / Disease Biomarker (G5465)

Target Name: PPARA

NCBI ID: G5465

PPARA

PPARA: A Drug Target / Disease Biomarker

PPARA (peroxisome proliferator-activated receptor alpha) is a protein that is expressed in various tissues throughout the body. It is a key regulator of cell growth, metabolism, and adhesion, and is involved in the development and progression of many diseases, including cancer.

PPARA has also been identified as a potential drug target and biomarker for the treatment of various diseases, including cancer, obesity, and diabetes. Its role in these conditions has led to a growing interest in the use of PPARA as a therapeutic approach.

At its core, PPARA is a transcription factor that plays a crucial role in the regulation of gene expression. It is composed of four transmembrane domains: an extracellular domain, a transmembrane domain, an intracellular domain, and an N-terminus. The extracellular domain is responsible for the protein's ability to interact with DNA, while the transmembrane domain is responsible for its ability to interact with other proteins and molecules within the cell membrane. The intracellular domain is responsible for the protein's ability to interact with the cytoskeleton, and the N-terminus is responsible for the protein's ability to interact with other proteins and molecules within the cell membrane.

PPARA is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and adhesion. It is also involved in the regulation of cellular metabolism, including the regulation of glucose and lipid metabolism.

In addition to its role in cellular processes, PPARA is also involved in the regulation of inflammation and immune responses. It is has been shown to play a key role in the regulation of inflammation and immune responses, and is involved in the regulation of the immune response.

PPARA has also been identified as a potential drug target for the treatment of cancer, obesity, and diabetes. Its role in these conditions has led to a growing interest in the use of PPARA as a therapeutic approach.

In cancer, PPARA has been shown to play a key role in the regulation of cell growth, metabolism, and adhesion. It is also involved in the regulation of the immune response, and has been shown to promote the growth and survival of cancer cells.

In obesity, PPARA has been shown to play a key role in the regulation of energy metabolism and adhesion. It is also involved in the regulation of the immune response, and has been shown to contribute to the development and progression of obesity.

In diabetes, PPARA has been shown to play a key role in the regulation of insulin sensitivity and inflammation. It is also involved in the regulation of the immune response, and has been shown to contribute to the development and progression of diabetes.

In addition to its role in diseases, PPARA has also been shown to play a key role in the regulation of normal cellular processes. It is involved in the regulation of cell cycle progression, and has been shown to play a key role in the regulation of cell division.

PPARA has also been shown to be involved in the regulation of cellular signaling pathways. It is involved in the regulation of the PI3K/Akt signaling pathway, and has been shown to play a key role in the regulation of this pathway.

In conclusion, PPARA is a protein that is involved in a wide range of cellular processes. Its role in the regulation of cell growth, differentiation, and adhesion, as well as its involvement in the regulation of inflammation and immune responses, make it an attractive target for the development of new therapeutic approaches for a wide range of diseases. Further research is needed to fully understand the role of PPARA in disease, and to develop effective therapies based on this protein.

Protein Name: Peroxisome Proliferator Activated Receptor Alpha

Functions: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2

The "PPARA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPARA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets