PPCDC (COAC_HUMAN), A Potential Drug Target and Biomarker (G60490)

Target Name: PPCDC

NCBI ID: G60490

PPCDC

PPCDC (COAC_HUMAN), A Potential Drug Target and Biomarker

Introduction

PPCDC (phosphorylated malonate transporter) is a protein that plays a critical role in the intracellular transport of phosphate groups, which are essential for various cellular processes. The human homolog of PPCDC, COAC\\_HUMAN, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

PPCDC: Structure and Function

PPCDC is a 21-kDa protein that consists of a catalytic core and a transmembrane region. The catalytic core consists of a unique ATP-binding site, a catalytic cycle intermediate, and a C-terminus that is involved in the transfer of phosphate groups. The transmembrane region is rich in electrolytes, including Na+, K+, and Cl-, which are crucial for maintaining the physiological membrane potential.

PPCDC functions as a transporter for the transport of phosphate groups from the cytosol to various organelles, including the endoplasmic reticulum (ER), mitochondria, and the cytosol. Phosphate groups are essential for various cellular processes, including DNA replication, protein synthesis, and signaling pathways. The efficient transport of phosphate groups is critical for maintaining cellular homeostasis and for the proper functioning of various cellular processes.

Mutations in PPCDC Genes

Mutations in PPCDC genes have been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The most well-known mutation is the missense mutation that is associated with the neurodegenerative disease, ALS (Amyotrophic Lateral Sclerosis), which is caused by the progressive loss of motor neurons.

The missense mutation in the PPCDC gene has been shown to disrupt the normal transport of phosphate groups, leading to an accumulation of toxic phosphate intermediates in the cytosol. This accumulation of phosphate intermediates has been linked to the development of neurodegenerative symptoms, including muscle weakness, paralysis, and cognitive impairments.

Another mutation in PPCDC that has been associated with disease is the insertion of a foreign DNA sequence at its C-terminus. This mutation has been shown to disrupt the normal transport of phosphate groups and to contribute to the development of various diseases, including cancer.

Potential Drug Target and Biomarker

The efficient transport of phosphate groups is critical for maintaining cellular homeostasis and for the proper functioning of various cellular processes. The missense mutation in PPCDC that is associated with the neurodegenerative disease, ALS, provides a target for the development of therapeutic interventions.

Currently, researchers are exploring the use of small molecule compounds to modulate the function of the PPCDC gene to treat various diseases. These small molecule compounds can be screened and developed as drug precursors or biomarkers. In addition, mutations in the PPCDC gene are also related to a variety of diseases, providing important clues for studying the pathogenesis of these diseases.

Conclusion

PPCDC (phosphorylated malonate transporter) is a protein that plays a critical role in the intracellular transport of phosphate groups, which are essential for various cellular processes. The human homolog of PPCDC, COAC\\_HUMAN, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The efficient transport of phosphate groups is critical for maintaining cellular homeostasis and for the proper functioning of various cellular processes. The missense mutation associated with the neurodegenerative disease , ALS, provides a target for the development of therapeutic interventions.

Protein Name: Phosphopantothenoylcysteine Decarboxylase

Functions: Catalyzes the decarboxylation of the cysteine moiety of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine and this reaction forms part of the biosynthesis of coenzyme A

The "PPCDC Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPCDC comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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