ARHGAP11B: Potential Drug Target and Biomarker for Disease (G89839)

Target Name: ARHGAP11B

NCBI ID: G89839

ARHGAP11B

ARHGAP11B: Potential Drug Target and Biomarker for Disease

ARHGAP11B (MGC104367) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and kidneys. It is a member of the ARHGAP gene family, which encodes a protein that is involved in the regulation of cell survival and growth.

The ARHGAP gene family has been identified as a potential drug target in the development of various diseases, including cancer, neurodegenerative diseases, and respiratory diseases. The protein encoded by the ARHGAP11B gene has been shown to play a role in the regulation of cell survival and growth, and may be a useful biomarker for the diagnosis and treatment of these diseases.

The ARHGAP11B protein is composed of 211 amino acid residues and has a calculated molecular weight of 23.9 kDa. It is expressed in a variety of tissues, including the brain, heart, lungs, and kidneys, and is involved in the regulation of cell survival and growth.

The ARHGAP11B protein is involved in the regulation of cell adhesion and migration. It has been shown to play a role in the regulation of tight junction formation, which is the process by which cells stick together to form tissues and organs. The ARHGAP11B protein is also involved in the regulation of cell survival and growth, as well as the regulation of cell signaling pathways that are involved in cell survival and growth.

The ARHGAP11B protein is also involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function and the production of pro-inflammatory cytokines. The ARHGAP11B protein may also be involved in the regulation of chronic pain, as it has been shown to play a role in the regulation of pain signaling in the brain.

The ARHGAP11B protein is also involved in the regulation of cell signaling pathways that are involved in cell survival and growth. It has been shown to play a role in the regulation of cell signaling pathways that are involved in cell survival and growth, including the regulation of angiogenesis, which is the process by which new blood vessels are formed.

The ARHGAP11B protein is also involved in the regulation of cell signaling pathways that are involved in cell survival and growth. It has been shown to play a role in the regulation of cell signaling pathways that are involved in cell survival and growth, including the regulation of cell cycle progression.

In conclusion, ARHGAP11B (MGC104367) is a protein that is involved in the regulation of cell survival and growth, as well as the regulation of cell signaling pathways that are involved in cell growth and development. It may be a useful biomarker for the diagnosis and treatment of diseases that are characterized by these processes, including cancer, neurodegenerative diseases, and respiratory diseases. Further research is needed to fully understand the role of ARHGAP11B in these diseases and to develop effective treatments.

Protein Name: Rho GTPase Activating Protein 11B

Functions: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex (PubMed:25721503, PubMed:27957544, PubMed:30484771, PubMed:32554627, PubMed:33938018). Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion (PubMed:25721503). Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP): delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+) concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation (PubMed:31883789). Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development (PubMed:25721503, PubMed:27957544)

The "ARHGAP11B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARHGAP11B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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