Understanding the Role of ARIH2 in T Cell Development and Function

Target Name: ARIH2

NCBI ID: G10425

ARIH2

Understanding the Role of ARIH2 in T Cell Development and Function

ARIH2 (ARIH2_HUMAN) is a protein that is expressed in human tissues and has been identified as a potential drug target for the treatment of various diseases, including cancer. The ARIH2 protein is a key component of the immune response and has been shown to play a role in the regulation of T cell responses.

One of the key functions of the ARIH2 protein is its role in the regulation of T cell development and function. T cells are a type of immune cell that play a critical role in the immune response to infections and diseases. They are responsible for recognizing and responding to foreign substances in the body, and are a key part of the immune system.

ARIH2 has been shown to play a key role in the regulation of T cell development and function. It has been shown to promote the growth and proliferation of T cells, and to regulate the development of T cell receptor (TCR) diversity. TCR is a protein that is found on the surface of T cells and plays a critical role in the immune response.

ARIH2 has also been shown to play a key role in the regulation of T cell responses to infections and diseases. It has been shown to promote the activation and proliferation of T cells in response to the presence of foreign substances in the body, such as viruses or bacteria.

In addition to its role in T cell development and function, ARIH2 has also been shown to play a key role in the regulation of inflammation. It has been shown to promote the production of pro-inflammatory cytokines in response to the presence of foreign substances in the body, and to regulate the production of anti-inflammatory cytokines in response to the presence of anti-inflammatory drugs.

ARIH2 is also a potential drug target for the treatment of various diseases, including cancer. Studies have shown that ARIH2 is often overexpressed in various types of cancer, and that inhibition of ARIH2 has been shown to be effective in treating these diseases.

In conclusion, ARIH2 is a protein that is expressed in human tissues and has been identified as a potential drug target for the treatment of various diseases, including cancer. Its role in the regulation of T cell development and function, as well as its role in the regulation of inflammation, make it an attractive target for drug development. Further research is needed to fully understand the role of ARIH2 in the immune response and its potential as a drug target.

Protein Name: Ariadne RBR E3 Ubiquitin Protein Ligase 2

Functions: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006)

The "ARIH2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARIH2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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