Unique ARHGEF10: Potential Drug Target & Biomarker (G9639)

Target Name: ARHGEF10

NCBI ID: G9639

ARHGEF10

Unique ARHGEF10: Potential Drug Target & Biomarker

ARHGEF10 (GEF10) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a key role in cellular signaling.

ARHGEF10 is unique among GPCR family members because of its unique structure and function. Unlike most GPCRs, which have a single transmembrane domain and a large extracellular loop, ARHGEF10 has a double transmembrane domain and a unique N-terminal region that contains a putative cytoplasmic domain . This unique structure allows ARHGEF10 to interact with various intracellular signaling molecules, including protein kinases and small molecules.

ARHGEF10 is also unique in its function, as it is involved in a wide range of physiological processes in the body. It has been shown to play a key role in the regulation of pain, inflammation, and cell survival. For example, ARHGEF10 has been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. It is also involved in the regulation of inflammation, including the regulation of immune cell function and the production of pro-inflammatory cytokines.

Due to its unique structure and function, ARHGEF10 has been identified as a potential drug target. Researchers have identified several small molecules that can interact with ARHGEF10 and have shown that these molecules can modulate its activity. These small molecules include inhibitors of protein kinases, such as inhibitors of the serine/threonine kinase (PKA) and calcitonin gene-related protein (CGRP), as well as agonists of GPCRs, such as the neurotransmitter naltrexone.

In addition to its potential as a drug target, ARHGEF10 is also a valuable biomarker for a variety of diseases. Its expression has been shown to be elevated in a wide range of diseases, including neurodegenerative diseases, cancer, and autoimmune disorders. This makes it a potential biomarker for these diseases and may be useful in the development of new diagnostic tests and therapies.

Overall, ARHGEF10 is a unique and highly promising protein that has the potential to be a drug target and a valuable biomarker for a wide range of diseases. Further research is needed to fully understand its function and to develop effective therapies based on its unique properties.

Protein Name: Rho Guanine Nucleotide Exchange Factor 10

Functions: May play a role in developmental myelination of peripheral nerves

The "ARHGEF10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARHGEF10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets