ARHGAP44: A Protein Involved in Cell Signaling and Cancer Development

Target Name: ARHGAP44

NCBI ID: G9912

ARHGAP44

ARHGAP44: A Protein Involved in Cell Signaling and Cancer Development

ARHGAP44 (also known as RICH2) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the ARG/GAP family of proteins, which are involved in a variety of cellular processes, including cell signaling, DNA replication, and protein synthesis.

One of the unique features of ARHGAP44 is its ability to interact with the protein p21, which is a key regulator of the T-cell receptor, a protein that is important for cell signaling and division. When ARHGAP44 is activated, it can cause p21 to enter the cytoplasm, which is the fluid inside the cell. This interaction between ARHGAP44 and p21 has important implications for the regulation of cellular processes, including cell signaling, cell division, and the development of cancer.

In addition to its role in cell signaling, ARHGAP44 has also been shown to play a role in the regulation of gene expression. When ARHGAP44 is activated, it can cause the genes that are expressed in the cell to be translated into proteins, which can lead to the production of a variety of different proteins. This regulation of gene expression is important for the development and maintenance of tissues and organs, including the development of new tissues and organs for transplantation.

Another unique feature of ARHGAP44 is its ability to interact with the protein known as p53, which is a protein that is involved in the regulation of DNA replication and the cell cycle. When ARHGAP44 is activated, it can cause p53 to enter the cytoplasm, which is the fluid inside the cell. This interaction between ARHGAP44 and p53 has important implications for the regulation of cell growth and division, as well as the risk of cancer.

In conclusion, ARHGAP44 is a protein that is involved in a variety of cellular processes, including cell signaling, DNA replication, and protein synthesis. Its unique ability to interact with the protein p21 and the protein p53 makes it an attractive drug target and a potential biomarker for a variety of diseases. Further research is needed to fully understand the role of ARHGAP44 in cellular processes and its potential as a drug target.

Protein Name: Rho GTPase Activating Protein 44

Functions: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity)

The "ARHGAP44 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARHGAP44 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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