ARHGEF12: A GPCR-Based Drug Target (G23365)

Target Name: ARHGEF12

NCBI ID: G23365

ARHGEF12

ARHGEF12: A GPCR-Based Drug Target

ARHGEF12 (KIAA0382) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and lungs. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a critical role in cellular signaling.

ARHGEF12 is characterized by its extracellular domain, which consists of a single transmembrane alpha-helical domain. This domain is responsible for the protein's ability to interact with various signaling molecules, including GABA, a neurotransmitter that plays a critical role in modulating brain activity.

ARHGEF12 is also characterized by its intracellular domain, which consists of a single transmembrane beta-sheet. This domain is responsible for the protein's ability to interact with various intracellular signaling molecules, including tyrosine kinase (TK), a protein that is involved in the signaling pathway that regulates cell growth and differentiation.

ARHGEF12 is also involved in several different signaling pathways, including the regulation of ion channels, the production of reactive oxygen species (ROS), and the regulation of protein levels.

One of the most promising aspects of ARHGEF12 is its potential as a drug target. The GPCR family is a common target for drug development, as many drugs that are used to treat a wide range of diseases work by modulating the activity of GPCRs.

ARHGEF12 is also a good candidate for a drug target because of its involvement in several different signaling pathways. For example, the regulation of ion channels by ARHGEF12 is involved in the regulation of the resting membrane potential of neurons, which is critical for their ability to generate action potentials (REs).

Additionally, the production of ROS by ARHGEF12 is involved in the regulation of cell signaling pathways, which are critical for the development and progression of many diseases.

In conclusion, ARHGEF12 is a protein that is expressed in various tissues throughout the body and is involved in several different signaling pathways. Its potential as a drug target is due to its involvement in these signaling pathways and its ability to interact with various signaling molecules. Further research is needed to fully understand the role of ARHGEF12 in the regulation of cellular signaling pathways and its potential as a drug target.

Protein Name: Rho Guanine Nucleotide Exchange Factor 12

Functions: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13

The "ARHGEF12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARHGEF12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets