ARID1A: Key Regulator of Cell Division and Potential Drug Target

Target Name: ARID1A

NCBI ID: G8289

ARID1A

ARID1A: Key Regulator of Cell Division and Potential Drug Target

ARID1A (BAF250) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a key regulator of cell division and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of ARID1A is its role in regulating the formation of cancer cells. It has been shown to promote the growth and survival of cancer cells, and to contribute to the development of cancer stem cells. This is thought to happen by blocking the inhibition of cell division that normally occurs in response to environmental stressors, such as DNA damage or oncogenes.

Another function of ARID1A is its role in the regulation of cellular processes that are critical for maintaining tissue homeostasis. It is involved in the regulation of cell adhesion, migration, and the formation of tissues and organs, and is thought to play a key role in the development and maintenance of tissues and organs.

In addition to its role in cell regulation, ARID1A is also a potential drug target. Its involvement in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders, makes it an attractive target for researchers to explore for new treatments.

One approach to targeting ARID1A is to use small molecules, such as drugs that can modulate its activity. These drugs can be designed to interact with ARID1A and to either activate or inhibit its function. By using these drugs, researchers can study the effects of ARID1A on cellular processes and determine how it contributes to the development and progression of various diseases.

Another approach to targeting ARID1A is to use antibodies that are designed to selectively bind to it. These antibodies can be used to either block ARID1A's activity or to label it so that it can be targeted by other immune cells. By using antibodies, researchers can study the effects of ARID1A on cellular processes and determine how it contributes to the development and progression of various diseases.

Overall, ARID1A is a protein that is involved in a number of important cellular processes and has been implicated in a variety of diseases. Its potential as a drug target makes it an attractive target for researchers to explore for new treatments. Further research is needed to fully understand the role of ARID1A in cellular processes and to determine its potential as a drug target.

Protein Name: AT-rich Interaction Domain 1A

Functions: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)

The "ARID1A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARID1A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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