HS6ST2: for Alzheimer's, Parkinson's and Huntington's Diseases

Target Name: HS6ST2

NCBI ID: G90161

HS6ST2

HS6ST2: for Alzheimer's, Parkinson's and Huntington's Diseases

Heparan sulfate 6-O-sulfotransferase 2 (HS6ST2) is a gene that encodes a protein located in the endoplasmic reticulum (ER) of the cell. The ER is a membrane-wrapped organelle, responsible for protein synthesis, quality control, and degradation. The HS6ST2 protein is involved in the process of sulfation, which is the modification of proteins with sulfate groups.

Sulfation is a crucial post-translational modification that plays a central role in various cellular processes, including cell signaling, inflammation, and stress resistance. It is a highly conserved enzyme, with a conserved active site and distinct subdomains, including a catalytic domain, a transmembrane region, and a cytoplasmic tail.

HS6ST2 is a member of the sulfate transport family 7, which includes proteins involved in the transport of sulfate across different cell membranes, including the inner mitochondrial membrane and the outer mitochondrial membrane. It is a key enzyme in the generation of reactive sulfate intermediates, which can modulate various cellular processes.

The HS6ST2 gene has been implicated in various diseases, including neurodegenerative disorders, autoimmune diseases, and developmental disorders. It is a potential drug target and a biomarker for several diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

One of the most significant findings related to HS6ST2 is its involvement in the development and progression of Alzheimer's disease. Alzheimer's disease is a neurodegenerative disorder characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain. Several studies have shown that HS6ST2 is involved in the production of beta-amyloid plaques and neurofibrillary tangles, and that its levels are decreased in individuals with Alzheimer's disease.

Other studies have also shown that HS6ST2 is involved in the regulation of neurotransmitter release, which is a crucial aspect of brain function. Studies have shown that HS6ST2 is involved in the synthesis and release of dopamine, a neurotransmitter that plays a crucial role in mood regulation , motivation, and pleasure.

Another potential application of HS6ST2 is its use as a biomarker for autoimmune diseases. Autoimmune diseases are a group of diseases in which the immune system attacks the body's own tissues. These diseases can cause a wide range of symptoms, including inflammation, fatigue, and damage to various organs.

HS6ST2 has been shown to be involved in the regulation of immune cell function, which is a crucial aspect of autoimmune diseases. Studies have shown that HS6ST2 is involved in the production of immune cells, including T cells and B cells, and that its levels are regulated by immune-related signaling pathways.

Finally, HS6ST2 has also been shown to be involved in the regulation of cell apoptosis, which is a natural process that helps the body remove damaged or dysfunctional cells. Cell apoptosis is a crucial aspect of tissue repair and regeneration, and is also involved in the regulation of pain perception.

In conclusion, HS6ST2 is a gene that encodes a protein involved in the process of sulfation, which is a crucial post-translational modification that plays a central role in various cellular processes. Its involvement in the development and progression of Alzheimer's disease, neurodegenerative disorders, autoimmune diseases, and cell apoptosis makes it a potential drug target and a biomarker for these diseases. Further research is needed to fully understand the role of HS6ST2 in these diseases and to develop effective treatments.

Protein Name: Heparan Sulfate 6-O-sulfotransferase 2

Functions: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate

The "HS6ST2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about HS6ST2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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