VAPA: A Protein in Cell-cell and Cell-extracellular Matrix Interactions in Various Diseases

Target Name: VAPA

NCBI ID: G9218

VAPA

VAPA: A Protein in Cell-cell and Cell-extracellular Matrix Interactions in Various Diseases

VAPA, or Vesicle-associated membrane protein-associated protein A, is a protein that is expressed in various cell types, including neurons, endothelial cells, and epithelial cells. It is a member of the transmembrane protein family and is involved in various cellular processes , including cell signaling, cell-cell adhesion, and cell-extracellular matrix interactions.

Recent studies have identified VAPA as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is because VAPA has been shown to play important roles in the development and progression of these diseases, and may be involved in the regulation of key cellular processes that contribute to their pathogenesis.

One of the key functions of VAPA is its role in cell-cell adhesion. Adhesion is the process by which cells stick together to form tissues and organs, and is critical for the development and maintenance of tissues and organs during development and throughout life. VAPA is involved in the formation of tight junctions, which are specialized junctions that form between adjacent cells and are critical for maintaining tissue structure and function.

In addition to its role in cell-cell adhesion, VAPA is also involved in the regulation of cell signaling. It has been shown to play important roles in the regulation of neurotransmitter signaling, which is the process by which neurotransmitters move between neurons transmit signals between. This is important for the function of the nervous system and is involved in the development and treatment of various neurological and psychiatric disorders.

VAPA's role in cell-extracellular matrix (ECM) interactions is also being targeted in the development of cancer. ECM interactions are critical for the regulation of cellular processes, including cell migration and the formation of cancer cells. VAPA has been shown to play important roles in the regulation of ECM interactions and may be involved in the development and progression of cancer.

In conclusion, VAPA is a protein that is involved in various cellular processes that are critical for the development and progression of various diseases. As a result, it is a potential drug target or biomarker for a variety of conditions, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of VAPA in these diseases and to develop effective treatments.

Protein Name: VAMP Associated Protein A

Functions: Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470)

The "VAPA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VAPA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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