VCAM1: A Protein in Cell-cell and Cell-extracellular Matrix Interactions, Inflammation and Immune Responses

Target Name: VCAM1

NCBI ID: G7412

VCAM1

VCAM1: A Protein in Cell-cell and Cell-extracellular Matrix Interactions, Inflammation and Immune Responses

VCAM1 (Integrin 伪6) is a protein that is expressed in many different tissues throughout the body, including the skin, hair, and nails. It is a member of the integrin family, which is a group of transmembrane proteins that play a critical role in cell-cell and cell-extracellular matrix interactions.

One of the unique features of VCAM1 is its ability to interact with integrin 伪5, which is also a member of the integrin family. This interaction between VCAM1 and 伪5 is important for the regulation of cell adhesion, migration, and invasion.

VCAM1 has also been shown to interact with various cytokines, including TGF-β1, which is a key regulator of cell growth and differentiation. This interaction between VCAM1 and TGF-β1 has been shown to play a role in the regulation of skin development and wound healing.

In addition to its role in cell-cell and cell-extracellular matrix interactions, VCAM1 has also been shown to play a role in the regulation of inflammation and immune responses. It has been shown to interact with various immune cells, including T cells and macrophages, and to be involved in the regulation of inflammation-induced pain.

VCAM1 is also a potential drug target, as it has been shown to play a role in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

One potential mechanism by which VCAM1 may be involved in cancer is its role in the regulation of cell adhesion and migration. Cancer cells often have altered levels of VCAM1 and are able to evade the normal cell-cell adhesion that is critical for tumor progression.

VCAM1 has also been shown to play a role in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to be caused by the build-up of abnormal proteins in the brain.

VCAM1 has also been shown to be involved in the regulation of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. These conditions are characterized by the immune system attacking the body's own tissues, and it is thought that VCAM1 may play a role in the regulation of this process.

In conclusion, VCAM1 is a protein that has been shown to play a variety of roles in cell-cell and cell-extracellular matrix interactions, as well as in the regulation of inflammation and immune responses. Its unique ability to interact with integrin 伪5 and other cytokines makes it a potential drug target for a variety of diseases. Further research is needed to fully understand the role of VCAM1 in these processes and to develop effective treatments.

Protein Name: Vascular Cell Adhesion Molecule 1

Functions: Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567)

The "VCAM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VCAM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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