Study on METTL21D's Role in Protein Expression and Stability (G79609)

Target Name: VCPKMT

NCBI ID: G79609

VCPKMT

Study on METTL21D's Role in Protein Expression and Stability

VCPKMT (Protein-lysine methyltransferase METTL21D) is a gene that has been well-studied for its role in the regulation of protein expression and stability in various organisms, including humans. The METTL21D gene has been shown to play a crucial role in the regulation of mitochondrial dynamics and protein homeostasis.

One of the key functions of METTL21D is its role in protein methylation. METTL21D is a protein-lysine methyltransferase, which means it adds a methyl group to specific lysine residues on target proteins. This modification has been shown to play a critical role in the regulation of protein stability, localization, and interactions with other cellular components.

In addition to its role in protein methylation, METTL21D is also involved in the regulation of protein expression and turnover. Studies have shown that METTL21D can interact with various transcription factors and regulatory proteins to regulate the expression of target genes. This interaction between METTL21D and transcription factors suggests that METTL21D may be a potential drug target or biomarker for a variety of diseases.

Another important function of METTL21D is its role in the regulation of mitochondrial dynamics. METTL21D is a member of the METT family of proteins, which are involved in the regulation of mitochondrial dynamics and structure. METTL21D has been shown to play a critical role in the regulation of mitochondrial protein homeostasis, including the levels of mitochondrial fission yeast and the stability of mitochondrial dynamics.

In conclusion, VCPKMT (Protein-lysine methyltransferase METTL21D) is a gene that has been well-studied for its role in the regulation of protein expression and stability in various organisms. The METTL21D gene has been shown to play a crucial role in the regulation of protein methylation, stability, and expression, as well as the regulation of mitochondrial dynamics. Based on these findings, METTL21D may be a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of METTL21D in the regulation of protein expression and stability.

Protein Name: Valosin Containing Protein Lysine Methyltransferase

Functions: Protein N-lysine methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity

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