ARPC3: A Potential Drug Target and Biomarker (G10094)

Target Name: ARPC3

NCBI ID: G10094

ARPC3

ARPC3: A Potential Drug Target and Biomarker

Apoptosis, or programmed cell death, is a natural mechanism that helps the body eliminate damaged or dysfunctional cells. In diseases such as cancer, apoptosis can be triggered or hindered, leading to the development of negative outcomes. The regulation of apoptosis is a complex process that involves multiple signaling pathways, including the angiogenesis-rich cell proliferation (ARPC) pathway. Angiogenesis is the process by which new blood vessels grow in the body, and it is closely associated with the development of many diseases, including cancer. The ARPC pathway plays a crucial role in the regulation of angiogenesis and is a potential drug target in cancer treatment.

ARPC3: The ARPC3 Pathway and Its Components

The ARPC pathway is a complex signaling pathway that involves the interaction of several proteins, including the transcription factor, NF-kappa-B, and the protein, p53. The ARPC pathway is involved in the regulation of cell proliferation, differentiation, and survival, and it is a key factor in the development of cancer.

The ARPC3 protein is a key component of the ARPC pathway. It is a nuclear protein that plays a role in the regulation of angiogenesis, cell survival, and apoptosis. The ARPC3 protein is composed of several domains, including a nuclear-membrane-spanning region, a cytoplasmic region, and a transmembrane region. The ARPC3 protein is involved in several signaling pathways, including the TGF-β pathway, the Wnt pathway, and the FGF pathway.

The TGF-β pathway is a well-established signaling pathway that is involved in the regulation of cell proliferation, differentiation, and survival. The TGF-β pathway is activated by the protein, TGF-β1, and it involves the regulation of the expression of several genes, including ARPC3. The ARPC3 protein is involved in the regulation of TGF-β1-induced angiogenesis and cell proliferation.

The Wnt pathway is a signaling pathway that is involved in the regulation of cell proliferation and survival. The Wnt pathway is activated by the protein, Wnt, and it involves the regulation of the expression of several genes, including ARPC3. The ARPC3 protein is involved in the regulation of Wnt-induced angiogenesis and cell survival.

The FGF pathway is a signaling pathway that is involved in the regulation of cell proliferation and survival. The FGF pathway is activated by the protein, FGF, and it involves the regulation of the expression of several genes, including ARPC3. The ARPC3 protein is involved in the regulation of FGF-induced angiogenesis and cell survival.

ARPC3 as a Drug Target

The ARPC3 protein is a potential drug target in cancer treatment. The ARPC3 protein is involved in the regulation of angiogenesis and cell survival, which are critical processes in the development of cancer. By targeting the ARPC3 protein, researchers may be able to inhibit the growth and survival of cancer cells.

ARPC3 can be targeted with small molecules, such as, inhibitors, antibodies, or vaccines. These molecules can be designed to interact with specific domains of the ARPC3 protein, such as the nuclear-membrane-spanning region, the cytoplasmic region, or the transmembrane region. By blocking the ARPC3 protein, researchers may be able to inhibit the growth and survival of cancer cells.

ARPC3 as a Biomarker

The ARPC3 protein can also be used as a biomarker for cancer. The ARPC3 protein is expressed in many types of cancer, including breast, ovarian, and colorectal cancers. The levels of the ARPC3 protein can be used to monitor the progression of cancer, the response to treatment, and the relapse of cancer.

The ARPC3 protein can also be used as a biomarker for

Protein Name: Actin Related Protein 2/3 Complex Subunit 3

Functions: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947)

The "ARPC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARPC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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