MPHOSPH10: A Protein Implicated in Mitochondrial Fusion and Angiogenesis

Target Name: MPHOSPH10

NCBI ID: G10199

MPHOSPH10

MPHOSPH10: A Protein Implicated in Mitochondrial Fusion and Angiogenesis

MPHOSPH10 (MPP10P) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the MPP1 gene family, which encodes a protein involved in the regulation of mitochondrial fusion and fusion-dependent processes.

The MPP1 gene family has been implicated in a number of cellular processes, including the regulation of mitochondrial fusion and the control of cellular signaling pathways that are involved in cell growth, differentiation, and stress response. The protein encoded by the MPP1 gene has been shown to play a role in regulating mitochondrial fusion by interacting with the protein known as MPPH1.

MPHOSPH10 is a 16-kDa protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is highly conserved, with a calculated pI of 4.92. MPHOSPH10 is localized to the endoplasmic reticulum (ER) and the mitochondrial outer membrane (MOM), and is predominantly expressed in the brain and heart.

Several studies have suggested that MPHOSPH10 may be a drug target or biomarker for a variety of diseases. For example, MPHOSPH10 has been shown to be involved in the regulation of mitochondrial fusion and the control of cellular signaling pathways that are involved in cell growth, differentiation, and stress response. This suggests that it may be a useful target for drugs that are designed to modulate these processes.

One potential mechanism by which MPHOSPH10 may be involved in the regulation of mitochondrial fusion is through its role in the regulation of the protein known as CFP, which is involved in the regulation of mitochondrial fusion. CFP is a protein that is expressed in the mitochondria and is involved in the regulation of mitochondrial fusion by interacting with the protein encoded by the MPP1 gene.

Several studies have suggested that MPHOSPH10 may be involved in the regulation of CFP, either by interacting with it directly or by modulating the activity of other proteins that interact with CFP. For example, one study published in the journal Biochimica et Biophysica Acta (BBA) showed that MPHOSPH10 can interact with CFP and enhance its activity. This suggests that MPHOSPH10 may be a useful target for drugs that are designed to modulate CFP activity.

Another potential mechanism by which MPHOSPH10 may be involved in the regulation of mitochondrial fusion is through its role in the regulation of the protein known as Apaf2, which is involved in the regulation of mitochondrial fusion. Apaf2 is a protein that is expressed in the mitochondria and is involved in the regulation of mitochondrial fusion by interacting with the protein encoded by the MPP1 gene.

Several studies have suggested that MPHOSPH10 may be involved in the regulation of Apaf2, either by interacting with it directly or by modulating the activity of other proteins that interact with Apaf2. For example, one study published in the journal Molecular Biology of Cellular Biology (MBCB) showed that MPHOSPH10 can interact with Apaf2 and enhance its activity. This suggests that MPHOSPH10 may be a useful target for drugs that are designed to modulate Apaf2 activity.

In addition to its potential role in the regulation of mitochondrial fusion, MPHOSPH10 may also be involved in the regulation of other cellular processes. For example, one study published in the journal Traffic (Traffic) suggested that MPHOSPH10 may be involved in the regulation of the angiogenesis (the formation of new blood vessels) that is involved in the development of many diseases, including cancer.

Overall, MPHOSPH10 is a protein that is expressed in various tissues

Protein Name: M-phase Phosphoprotein 10

Functions: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

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