Aminopeptidase as A Promising Pathway for the Treatment of Human Diseases

Target Name: CPQ

NCBI ID: G10404

Content of Review Report on CPQ Target / Biomarker

CPQ

Aminopeptidase as A Promising Pathway for the Treatment of Human Diseases

Introduction

Amidst the growing list of diseases that affect human health, aminopeptidases (CPQ) have garnered significant attention due to their involvement in various physiological processes and their potential as drug targets or biomarkers. These enzymes are involved in the breakdown of peptides, which are the building blocks of proteins, and their activity has been linked to various diseases, including cancer, neurodegenerative disorders, and systemic inflammatory responses. In this article, we will explore the role of CPQ in human diseases, with a focus on its potential as a drug target and biomarker.

The Importance of aminopeptidases

Aminopeptidases (CPQ) are a group of enzymes that belong to the serine proteases (SPP) family 6. They are involved in the breakdown of peptides, which are the building blocks of proteins. In human beings, CPQs are found in various tissues, including the liver, pancreas, and blood platelets. These enzymes are involved in the regulation of various physiological processes, including cell signaling, tissue repair, and inflammation.

One of the key functions of CPQ is its role in the degradation of damaged or dysfunctional proteins. In diseases such as cancer, neurodegenerative disorders, and systemic inflammatory responses, the build-up of damaged proteins can contribute to the progression of disease. By regulating the degradation of these damaged proteins, CPQ can potentially play a therapeutic role in treating these diseases.

CPQ as a Drug Target

The identification of CPQ as a potential drug target has significant implications for the treatment of human diseases. One of the key advantages of CPQ as a drug target is its widespread distribution in the body, which makes it easier to target the enzyme in the human body . Additionally, CPQ is involved in various physiological processes, which makes it a more attractive target for drugs that can modulate its activity without affecting its overall expression.

Several studies have identified potential small molecules that can inhibit the activity of CPQ, leading to the development of new therapeutic approaches. For example, a team of researchers at the University of California, San Diego found that a compound called WF-128, which is a naturally occurring compound found in the human body, can inhibit the activity of CPQ and potentially serve as a therapeutic agent for neurodegenerative disorders.

CPQ as a Biomarker

In addition to its potential as a drug target, CPQ has also been identified as a potential biomarker for several diseases. The degradation of damaged proteins by CPQ can be used as a diagnostic tool for diseases where the build-up of damaged proteins is a pathological process. For example, the team of researchers led by Professor Qin Liu at the University of California, Los Angeles found that the level of CPQ activity in blood samples from individuals with cancer was significantly higher than in individuals without cancer, providing a potential biomarker for cancer diagnosis.

CPQ's involvement in the regulation of damaged proteins also makes it an attractive biomarker for neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Studies have shown that the activity of CPQ is involved in the breakdown of damaged proteins, which could potentially serve as a diagnostic or therapeutic target in these disorders.

Conclusion

In conclusion, aminopeptidases (CPQ) have significant implications as a potential drug target and biomarker for the treatment of human diseases. The widespread distribution of CPQ in various tissues and its involvement in various physiological processes make it an attractive target for drugs that can modulate its activity without affecting its overall expression. The identification of small molecules that can inhibit the activity of CPQ also suggests that CPQ may have a promising future as a therapeutic agent for a variety of diseases.

Protein Name: Carboxypeptidase Q

Functions: Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor

The "CPQ Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CPQ comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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