SPAG5: A Potential Drug Target for Cancer Treatment (G10615)

Target Name: SPAG5

NCBI ID: G10615

SPAG5

SPAG5: A Potential Drug Target for Cancer Treatment

SPAG5, also known as Mitotic spindle-associated protein p126, is a protein that is expressed in a variety of tissues, including muscle, neural, and epithelial cells. It is a key component of the mitotic spindle, which is a structure that forms during cell division and is responsible for organizing the chromosomes during mitosis.

SPAG5 has been shown to play a critical role in the regulation of mitosis, and is expressed at high levels in rapidly dividing tissues such as cancer cells. It has also been shown to interact with several other proteins, including the protein tau, which is also known for its role in the regulation of mitosis.

Recent studies have suggested that SPAG5 may be a potential drug target for the treatment of cancer. One reason for this is that SPAG5 has been shown to be involved in the regulation of cell proliferation, which is a key factor in the development and progression of many types of cancer. Additionally, SPAG5 has been shown to interact with several proteins that have been implicated in the development and progression of cancer, including the oncogene transforming growth factor (TGF-2).

Another potential mechanism by which SPAG5 may be involved in the development and progression of cancer is its role in the regulation of cell adhesion. SPAG5 has been shown to play a role in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. This is important for the development and maintenance of tissues and organs, and is also important for the regulation of normal growth and development.

SPAG5 has also been shown to play a role in the regulation of cell migration, which is the process by which cells move from one location to another in the body. This is important for the development and maintenance of tissues and organs, and is also important for the regulation of normal growth and development.

In conclusion, SPAG5 is a protein that has been shown to play a critical role in the regulation of mitosis and cell division. Its involvement in these processes makes it a potential drug target for the treatment of cancer. Further research is needed to fully understand the role of SPAG5 in the regulation of cell division and its potential as a drug target.

Protein Name: Sperm Associated Antigen 5

Functions: Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase (PubMed:11724960, PubMed:12356910, PubMed:27462074). Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:17664331, PubMed:27462074). In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes (PubMed:18361916, PubMed:21402792). Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis (PubMed:23953116). May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU (PubMed:18055457)

The "SPAG5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SPAG5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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