POLR3F: A Key Enzyme in DNA Replication and Transcription (G10621)

Target Name: POLR3F

NCBI ID: G10621

POLR3F

POLR3F: A Key Enzyme in DNA Replication and Transcription

POLR3F, or poly(A)/poly(T) RNA-converting enzyme 3F, is a key enzyme in the process of DNA replication and transcription in eukaryotic cells. It is a 72-kDa protein that is found in the nucleus and is responsible for converting DNA strands to RNA strands during the process of transcription.

POLR3F is a subunit of the DNA-directed RNA polymerase III (RNA polymerase III) complex, which is a complex of several proteins that are involved in the process of transcription. The RNA polymerase III complex is responsible for generating RNA from DNA templates in the nucleus.

POLR3F is a critical enzyme in the RNA polymerase III complex because it is the enzyme that converts the double-stranded DNA template to double-stranded RNA during the transcription process. The double-stranded DNA template is generated by the complex's other subunits, which include the core RNA polymerase (CRP), RNA-catalytic subunit (RCS), and the linker RNA (LS).

POLR3F is a protein that contains 215 amino acids and has a calculated molecular mass of 21.9 kDa. It has a single domain that consists of a catalytic core and a hypervariable region (HVR). The catalytic core of POLR3F consists of a nucleotide-binding domain (NBD) and a base-pair recognition domain (BPRD). The NBD is responsible for binding to the double-stranded DNA template, while the BPRD is responsible for recognizing the base pairs of the DNA template during the transcription process.

POLR3F is a protein that has been identified as a potential drug target in several diseases. For example, POLR3F has been shown to be involved in the development of cancer, and it has been suggested as a potential therapeutic target for cancer treatment. Additionally, POLR3F has also been associated with several neurological diseases, including Alzheimer's disease and Parkinson's disease.

One of the reasons why POLR3F has been identified as a potential drug target is because it is involved in the process of transcription, which is the process by which the instructions in the DNA template are used to generate a protein. This means that any drug that can inhibit the activity of POLR3F would be able to disrupt the transcription process, potentially leading to a wide range of negative effects.

Another potential mechanism by which POLR3F can be targeted is by its role in the development of cancer. PolR3F has been shown to be involved in the regulation of gene expression in cancer cells, and it has been suggested as a potential therapeutic target for cancer treatment. By inhibiting the activity of POLR3F, researchers may be able to reduce the amount of RNA produced by cancer cells, which could lead to a reduction in cell growth and the development of new cancerous tumors.

In addition to its potential role as a drug target, POLR3F has also been identified as a potential biomarker for several diseases. For example, POLR3F has been shown to be involved in the development of Alzheimer's disease, and it has been suggested as a potential diagnostic biomarker for this disease. Additionally, POLR3F has also been shown to be involved in the development of Parkinson's disease, and it has been suggested as a potential diagnostic biomarker for this disease.

In conclusion, POLR3F is a protein that is involved in the process of transcription in eukaryotic cells. It is a critical enzyme in the DNA-directed RNA polymerase III complex and has been identified as a potential drug target and biomarker for several diseases. Further research is needed to fully understand the role of POLR3F in transcription and its potential as a therapeutic or diagnostic tool.

Protein Name: RNA Polymerase III Subunit F

Functions: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus (PubMed:30211253). Acts as nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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