POM121L9P: A Potential Drug Target and Biomarker for Transmembrane Nucleoporin-Like 9

Target Name: POM121L9P

NCBI ID: G29774

POM121L9P

Other Name(s): POM121 transmembrane nucleoporin like 9, pseudogene | UNQ2565 | DKFZP434P211

POM121L9P: A Potential Drug Target and Biomarker for Transmembrane Nucleoporin-Like 9

POM121L9P, also known as POM121 transmembrane nucleoporin-like 9 (TMN-9), is a protein that belongs to the subfamily of nucleoporin-like proteins (NOPs). TMN-9 is a putative pseudogene that has not been found in any mammalian species. It is characterized by its transmembrane domain, which is responsible for its unique structure and function.

TMN-9 functions as a nucleoporin-like protein, which plays a critical role in the regulation of nuclear transport and the control of cell proliferation. The nucleoporin-like proteins are involved in the formation of the nuclear envelope, which is responsible for maintaining the integrity of the nuclear genome. They also interact with various nuclear proteins, including histones and transcription factors, to regulate gene expression.

POM121L9P has been identified as a potential drug target due to its unique structure and its involvement in the regulation of nuclear transport. The development of new therapeutics for TMN-9 could be a valuable approach to treat various diseases, including cancer, neurodegenerative diseases, and genetic disorders.

Structure and Function

The structure of POM121L9P is unique among TMN-9s. It consists of a transmembrane domain and a cytoplasmic tail. The transmembrane domain is characterized by a long, N-terminal coiled-coil, which is responsible for the formation of a pore in the membrane. This pore allows TMN-9 to interact with various nuclear proteins.

The cytoplasmic tail of TMN-9 is also noteworthy. It contains a number of conserved domains, including a nucleotide-binding oligomerization domain (NBO), a zinc finger, and a leucine-rich repeat (LRR). These domains are involved in the regulation of DNA binding, protein-protein interaction, and protein stability, respectively.

TMN-9 functions as a nucleoporin-like protein by regulating the nuclear transport of various molecules, including nucleosomes, histones, and transcription factors. It does this by interacting with the nuclear envelope, which is a complex structure composed of various proteins that help to maintain the integrity of the membrane.

One of the unique features of TMN-9 is its ability to form a pore in the membrane that is large enough to allow large molecules to pass through. This pore is thought to be responsible for the regulation of the size of the nuclear envelope and the choice of proteins that can enter or exit the nucleus.

TMN-9 has been shown to play a critical role in the regulation of cell proliferation and cancer progression. It has been shown to be involved in the regulation of the G1/S transition, which is a critical step in the cell cycle that involves the entry of the cell into the G2 phase. TMN-9 has also been shown to be involved in the regulation of the G2/M transition, which is the stage of cell division where the cell prepares for mitosis.

In addition to its role in cell proliferation, TMN-9 has also been shown to be involved in the regulation of cell survival. It has been shown to play a critical role in the regulation of apoptosis, which is a normal form of cell death that helps to remove damaged or dysfunctional cells from the body.

TMN-9 has also been shown to be involved in the regulation of neurotransmitter release from neurons. It has been shown to play a critical role in the regulation of the release of neurotransmitters, such as dopamine and nitric oxide, which are involved in various neural functions.

POM121L9P as a drug target

The unique structure of POM121L9P makes it an attractive target for

Protein Name: POM121 Transmembrane Nucleoporin Like 9, Pseudogene

The "POM121L9P Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about POM121L9P comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets