RAD50: A Promising Drug Target / Biomarker (G10111)

Target Name: RAD50

NCBI ID: G10111

RAD50

RAD50: A Promising Drug Target / Biomarker

RAD50 is a drug target and a potential biomarker for various diseases, including cancer. Rad50 is a non-coding RNA molecule that is highly expressed in various tissues and cells, including the brain, heart, and gastrointestinal tract. It is a key regulator of DNA replication and has been involved in many important cellular processes.

The discovery of RAD50

RAD50 was first identified in the 1980s by researchers who were studying the regulation of DNA replication in cancer cells. They found that RAD50 was highly expressed in various tissues and cells, including the brain, and that it was involved in the regulation of DNA replication. Since then, researchers have continued to study RAD50 and its role in various diseases.

The biology of RAD50

RAD50 is a non-coding RNA molecule that is made up of 1,212 amino acid residues. It has a molecular weight of 17.9 kDa and a calculated pI of 5.8. RAD50 is highly expressed in various tissues and cells, including the brain, heart, and gastrointestinal tract. It is also expressed in various diseases, including cancer.

One of the key functions of RAD50 is its role in DNA replication. RAD50 is a key regulator of the DNA replication machinery, which is responsible for copying the genetic material from one generation to the next. RAD50 helps to ensure that the DNA replication machinery is properly regulated and that the genetic material is accurately copied.

Another function of RAD50 is its role in cell signaling. RAD50 has been shown to be involved in various signaling pathways, including the regulation of cell growth, differentiation, and survival. It has also been shown to play a role in the regulation of inflammation and immune responses.

The potential therapeutic uses of RAD50

The potential therapeutic uses of RAD50 are vast and varied. One of the main potential therapeutic uses of RAD50 is its use as a drug target. RAD50 has been shown to play a role in the regulation of many cellular processes, including cell growth, differentiation, and survival. As a result, RAD50 may be a useful target for the development of new drugs for a variety of diseases, including cancer.

In addition to its potential as a drug target, RAD50 has also been shown to be a potential biomarker for various diseases. Its high expression in various tissues and cells makes it a promising candidate for use as a biomarker for a variety of diseases. For example, RAD50 has been shown to be highly expressed in cancer cells and has been used as a biomarker for the diagnosis and treatment of various cancers.

Conclusion

In conclusion, RAD50 is a non-coding RNA molecule that is highly expressed in various tissues and cells. It is involved in many important cellular processes, including DNA replication and cell signaling. Its potential therapeutic uses are vast and varied, including its use as a drug target for the development of new drugs for various diseases. In addition, RAD50 has also been shown to be a potential biomarker for various diseases. Further research is needed to fully understand the role of RAD50 in various diseases and to develop new treatments based on its properties.

Protein Name: RAD50 Double Strand Break Repair Protein

Functions: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888)

The "RAD50 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RAD50 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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