DDX20: A Protein Involved in Cell Signaling and Gene Regulation

Target Name: DDX20

NCBI ID: G11218

DDX20

DDX20: A Protein Involved in Cell Signaling and Gene Regulation

DDX20 is a protein that is expressed in various tissues throughout the body, including the brain, spleen, and lymph nodes. It is a member of the dead box family of proteins, which are involved in the regulation of gene expression and cell signaling. Despite its importance in cellular signaling, little is known about the function or potential drug targets of DDX20.

The dead box family of proteins was identified in the 1990s as a source of gene expression in various organisms, including bacteria, yeast, and plants. These proteins are characterized by the presence of a conserved domain that includes a leucine-rich repeat (LRR) and a short amino acid tail. The LRR is thought to play a role in the formation of a protein-protein interaction complex, while the short tail is involved in stability and regulation of the protein.

DDX20 is a 20 kDa protein that is expressed in various tissues, including the brain, spleen, and lymph nodes. It is a member of the dead box family of proteins and is characterized by the presence of a conserved domain that includes a LRR and a short amino acid tail.

The function of DDX20 is not well understood, but it is thought to be involved in the regulation of gene expression and cell signaling. Several studies have suggested that DDX20 may be involved in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

One potential drug target for DDX20 is the inhibition of its activity. This can be achieved through various means, such as the use of small molecules or antibodies. The use of small molecules may be a useful approach for studying the function of DDX20, as it allows for the manipulation of its activity in a controlled manner. Antibodies, on the other hand, may be a useful approach for studying the interactions between DDX20 and other proteins.

Another potential approach to studying the function of DDX20 is the use of RNA interference (RNAi). RNAi is a technique that involves the use of small interfering RNA (siRNA) to knockdown the expression of specific genes. This technique may be a useful approach for studying the function of DDX20, as it allows for the manipulation of its expression in a controlled manner.

In conclusion, the function of DDX20 is not well understood, but it is thought to be involved in the regulation of gene expression and cell signaling. The use of small molecules, antibodies, and RNAi may be useful for studying the activity of DDX20 and its potential drug targets. Further research is needed to fully understand the role of DDX20 in cellular signaling and to develop effective treatments for its associated diseases.

Protein Name: DEAD-box Helicase 20

Functions: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)

The "DDX20 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDX20 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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