PSMC2: A Potential Drug Target for Cancer and Neurodegenerative Diseases

Target Name: PSMC2

NCBI ID: G5701

PSMC2

PSMC2: A Potential Drug Target for Cancer and Neurodegenerative Diseases

Post-Translational Modification Control (PSMC2) is a protein that plays a crucial role in regulating various cellular processes in the body. It is a protein that is involved in the modification of several different proteins, including tyrosine, which is a key modification that enables proteins to interact with other proteins and play a role in cell signaling.

PSMC2 is a member of the PSMC family, which is known for its role in regulating protein stability and localization. The PSMC family also includes other proteins, including PSMC1 and PSMC3, which are involved in the same process.

Drug Targeting

PSMC2 has been identified as a potential drug target for several different diseases. One of the main reasons for this is the fact that PSMC2 is involved in many different cellular processes, which makes it an attractive target for drugs that can modulate its activity.

For example, several studies have suggested that PSMC2 may be a useful target for diseases that are characterized by the overproduction of proteins, such as cancer. This is because PSMC2 is involved in the regulation of protein stability and localization, which may be disrupted in cancer cells.

Another potential application of PSMC2 as a drug target is the treatment of neurodegenerative diseases, such as Alzheimer's disease. This is because PSMC2 is involved in the regulation of the stability and localization of the neurotransmitter acetylcholine, which is a key component of the neurotransmitter system.

Biomarker

PSMC2 has also been identified as a potential biomarker for several different diseases. For example, some studies have suggested that PSMC2 may be a useful biomarker for the early detection of cancer, because its activity is often altered in cancer cells.

In addition, PSMC2 has been shown to be involved in the regulation of several different cellular processes, which makes it an attractive target for biomarkers that can be used to monitor the effects of drugs on these processes. For example, some studies have suggested that PSMC2 may be a useful biomarker for the treatment of neurodegenerative diseases, because its activity is often altered in these conditions.

Conclusion

PSMC2 is a protein that is involved in the regulation of several different cellular processes, including tyrosine modification. It has been identified as a potential drug target for several different diseases, including cancer and neurodegenerative diseases. Further research is needed to fully understand the role of PSMC2 in these processes and to develop effective treatments.

Protein Name: Proteasome 26S Subunit, ATPase 2

Functions: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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