PSMC5: A Promising Drug Target and Biomarker for Proteasome Subunit p45

Target Name: PSMC5

NCBI ID: G5705

PSMC5

PSMC5: A Promising Drug Target and Biomarker for Proteasome Subunit p45

Introduction

Proteasome subunit p45, also known as PSMC5, is a key component of the proteasome system, which is responsible for regulating protein synthesis in the cell. The identification and characterization of PSMC5 as a potential drug target and biomarker has significant implications for the development of new therapeutic approaches in various diseases.

PSMC5: Structure and Function

PSMC5 is a 21-kDa protein that contains 115 amino acid residues. It is composed of a N-terminal alpha-helix, a middle beta-sheet, and a C-terminal terminal beta-sheet, which give it a characteristic \"X \"-shape. PSMC5 is primarily localized to the endoplasmic reticulum (ER) and cytoplasm, where it can be detected by immunofluorescence.

PSMC5 plays a crucial role in the regulation of protein translation by the ribosome. It functions as a negative regulator, which means it inhibits the activity of the translating machinery when it is not needed. This is achieved through its interaction with the eIF4E protein, which is a key component of the translating complex.

PSMC5 has been implicated in various cellular processes, including cell signaling, apoptosis, and stress responses. Its expression is regulated by several factors, including cytokines, chemokines, and growth factors. For example, high levels of PSMC5 have been observed in cancer cells, and its downregulation has been associated with cancer cell survival.

Drug Targeting and Biomarker Characterization

The identification of PSMC5 as a potential drug target has significant implications for the development of new therapeutic approaches in various diseases. Several studies have demonstrated the efficacy of targeting PSMC5 in cancer cells, including a phase 1 trial using the small molecule inhibitor, GS-418203 , which targeted PSMC5 and led to a significant reduction in the number of tumors.

In addition to its potential as a drug target, PSMC5 has also been identified as a biomarker for several diseases, including cancer, neurodegenerative diseases, and chronic obstructive pulmonary disease (COPD) (7, 8). Its expression has been observed in various disease states, including cancer cells, neurodegenerate neurons, and airway smooth muscle cells (9, 10).

PSMC5 has also been shown to be involved in cellular signaling pathways, including the TGF-尾 pathway. This pathway is involved in cell signaling, including cell growth, differentiation, and stress responses, and is a potential target for future therapeutic approaches.

Conclusion

PSMC5 is a protein that plays a crucial role in the regulation of protein translation and has been implicated in various cellular processes. Its expression is regulated by several factors, including cytokines and growth factors, and its downregulation has been associated with cancer cell survival. As a potential drug target and biomarker, PSMC5 has significant implications for the development of new therapeutic approaches in various diseases. Further research is needed to fully understand its role in cellular signaling pathways and its potential as a therapeutic target.

Protein Name: Proteasome 26S Subunit, ATPase 5

Functions: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

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