PSMD11: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Target Name: PSMD11

NCBI ID: G5717

PSMD11

PSMD11: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Introduction

Proteasomes are complex protein structures that play a crucial role in regulating protein synthesis and degradation in eukaryotic cells. The 26S subunit of the proteasome, also known as PSMD11, is a key component of this complex protein machinery. Mutations in the PSMD11 gene have been implicated in a range of diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. As a result, PSMD11 has emerged as a promising drug target and biomarker for a variety of diseases.

PSMD11 Structure and Function

The PSMD11 protein is a 26S subunit of the proteasome, which is composed of 28 different proteins that form a highly specialized protein-protein interaction network. The 26S subunit is a 21 kDa protein that contains several important functions, including:

1. Non-ATPase activity: The 26S subunit contains a catalytic domain that is responsible for theATPase activity of the protein. This activity is essential for the efficient transfer of phosphate groups from ATP to the protein-protein interface, which is critical for protein -protein interactions and subsequent protein activation.
2. Transcript variant: PSMD11 has several transcript variants, which have been implicated in different cellular processes and biological processes. One of the most well-studied variants is the translation-initiation variant (PSMD11-IT), which has been shown to play a role in the regulation of protein synthesis and has been linked to various cellular processes, including cell growth, differentiation, and stress response.
3. Diverse functions: PSMD11 has been shown to participate in a variety of cellular processes, including protein-protein interactions, ubiquitination, and protein degradation. Its functions have been implicated in the regulation of various cellular processes, including cell growth, differentiation, and stress response.

PSMD11 as a Drug Target

The PSMD11 protein has been identified as a potential drug target due to its diverse functions and its involvement in various cellular processes. Several studies have shown that PSMD11 can be targeted by small molecules and have been used as lead compounds for drug development.

One of the most promising strategies for targeting PSMD11 is the use of small molecules that can inhibit its ATPase activity or its ability to form protein-protein interactions. Chemical libraries have been screened to identify compounds that can inhibit PSMD11 activity, and several compounds have been shown to be effective in cell-based assays.

PSMD11 as a Biomarker

PSMD11 has also been identified as a potential biomarker for various diseases. Its involvement in the regulation of cellular processes has been implicated in the development of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. As a result, the levels of PSMD11 have has been proposed as a potential biomarker for these diseases.

PSMD11 has been shown to be expressed in various tissues and has been used as a biomarker in a variety of disease models. For example, studies have shown that PSMD11 levels are elevated in cancer tissues and that inhibiting its activity has the potential to be a therapeutic approach for cancer treatment. Similarly, PSMD11 has been shown to be involved in the development of neurodegenerative disorders, and its inhibition has been shown to be a potential therapeutic approach for these disorders.

Conclusion

PSMD11 is a protein that plays a crucial role in the regulation of protein synthesis and degradation in eukaryotic cells. Its diverse functions and its involvement in various cellular processes make it an attractive drug target and a potential biomarker for a variety of diseases. The inhibition of

Protein Name: Proteasome 26S Subunit, Non-ATPase 11

Functions: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity

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•   general information;
•   protein structure and compound binding;
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•   expression level;
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