PSMC3: Protein Regulating Post-Translational Modification (G5702)

Target Name: PSMC3

NCBI ID: G5702

PSMC3

PSMC3: Protein Regulating Post-Translational Modification

Post-Translational Modification Control (PSMC3) is a protein that plays a crucial role in regulating various cellular processes. It is a protein that is involved in the modification of proteins, which is essential for their function and stability. PSMC3 is a key regulator of the DNA damage response, and it is involved in preventing the accumulation of genetic mutations that can lead to cancer.

PSMC3: The Protein Regulating Post-Translational Modification

Post-Translational Modification (PTM) is a process by which proteins are modified after their synthesis, but before they become functional. These modifications can include adding or removing functional groups such as phosphate or acetyl groups. PSMC3 is a protein that is involved in the regulation of PTMs. It is a seven-kDa protein that is expressed in various cell types, including muscle, nerve, and heart cells.

PSMC3: Structure and Function

The structure of PSMC3 is unique, as it is a member of the superfamily of ATP-binding proteins. It has a single polypeptide chain that is composed of 181 amino acids. PSMC3 has a characteristic Rossmann-fold, which is a type of ATP-binding site that is composed of a specific sequence of amino acids that can bind to ATP. This Rossmann-fold is the unique feature that sets PSMC3 apart from other proteins.

PSMC3 plays a crucial role in regulating the DNA damage response. It is involved in preventing the accumulation of genetic mutations that can lead to cancer. During the DNA damage response, PSMC3 helps to ensure that the DNA is repaired and that any mutations that have occurred are either repaired or removed.

PSMC3 is also involved in regulating the levels of protein in the cell. It helps to ensure that levels of certain proteins are maintained, while the levels of other proteins are reduced. This helps to ensure that cells have the right balance of proteins for optimal function.

PSMC3: Potential as a Drug Target

PSMC3 is a protein that has the potential to be a drug target. Its unique structure and function make it an attractive target for drug developers. PSMC3 has been shown to be involved in various cellular processes, including the regulation of the DNA damage response and the regulation of protein levels. This makes it an attractive target for drugs that are designed to modulate these processes.

One of the challenges in developing drugs that target PSMC3 is the fact that it is a protein that is expressed in various cell types. This makes it difficult to predict how a drug will affect PSMC3 in different cell types. Additionally, the structure of PSMC3 is unique, which makes it difficult to develop drugs that can specifically target it.

In conclusion, PSMC3 is a protein that plays a crucial role in regulating various cellular processes. Its unique structure and function make it an attractive target for drug developers. Further research is needed to understand the full potential of PSMC3 as a drug target.

Protein Name: Proteasome 26S Subunit, ATPase 3

Functions: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides

The "PSMC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PSMC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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